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Uridine phosphorylase
From Proteopedia
(Difference between revisions)
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**[[3o6v]], [[4k6o]] – VcUPP – ''Vibrio cholerae'' <br /> | **[[3o6v]], [[4k6o]] – VcUPP – ''Vibrio cholerae'' <br /> | ||
**[[4i2v]], [[4ny1]], [[4of4]] – UPP – ''Yersinia pseudotuberculosis''<br /> | **[[4i2v]], [[4ny1]], [[4of4]] – UPP – ''Yersinia pseudotuberculosis''<br /> | ||
| + | **[[4txh]] – SmUPP – ''Schistosoma mansoni'' <br /> | ||
*Uridine phosphorylase binary complex | *Uridine phosphorylase binary complex | ||
| Line 30: | Line 31: | ||
**[[2oec]], [[3c74]] – StUPP + inhibitor<br /> | **[[2oec]], [[3c74]] – StUPP + inhibitor<br /> | ||
**[[3ku4]] – bUPP + sulfate - bovine <br /> | **[[3ku4]] – bUPP + sulfate - bovine <br /> | ||
| - | **[[4e1v]] | + | **[[4e1v]], [[4ogk]], [[4ogl]] – SeUPP + nucleotide – ''Salmonella enterica''<br /> |
| - | + | ||
**[[4g8j]] – StUPP + 2’-deoxythymidine <br /> | **[[4g8j]] – StUPP + 2’-deoxythymidine <br /> | ||
**[[4lnh]] – VfUPP + sulfate – ''Vibrio fischeri'' <br /> | **[[4lnh]] – VfUPP + sulfate – ''Vibrio fischeri'' <br /> | ||
**[[4h1t]], [[4ip0]] – VcUPP + phosphate <br /> | **[[4h1t]], [[4ip0]] – VcUPP + phosphate <br /> | ||
| - | **[[4lzw]] – VcUPP + | + | **[[4lzw]], [[4oeh]], [[5c80]], [[5epu]], [[5efo]] – VcUPP + nucleotide <br /> |
| - | **[[ | + | **[[4txj]], [[4txl]], [[4txn]], [[4txm]] – SmUPP + nucleotide <br /> |
| + | **[[4u2k]] – VcUPP + anticancer compound <br /> | ||
**[[4jp5]] – UPP + sulfate – ''Yersinia pestis''<br /> | **[[4jp5]] – UPP + sulfate – ''Yersinia pestis''<br /> | ||
**[[4r2x]] – SoUPP + sulfate – ''Shewanella oneidensis''<br /> | **[[4r2x]] – SoUPP + sulfate – ''Shewanella oneidensis''<br /> | ||
| + | **[[4yjk]] – SoUPP (mutant) + uracil <br /> | ||
*Uridine phosphorylase ternary complex | *Uridine phosphorylase ternary complex | ||
Revision as of 08:20, 11 December 2016
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3D Structures of uridine phosphorylase
Updated on 11-December-2016
References
- ↑ Pizzorno G, Cao D, Leffert JJ, Russell RL, Zhang D, Handschumacher RE. Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update. Biochim Biophys Acta. 2002 Jul 18;1587(2-3):133-44. PMID:12084455
- ↑ Renck D, Santos AA Jr, Machado P, Petersen GO, Lopes TG, Santos DS, Campos MM, Basso LA. Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis. Invest New Drugs. 2014 Dec;32(6):1301-7. doi: 10.1007/s10637-014-0135-0. Epub, 2014 Jul 23. PMID:25052233 doi:http://dx.doi.org/10.1007/s10637-014-0135-0
- ↑ Lashkov AA, Sotnichenko SE, Prokofiev II, Gabdulkhakov AG, Agapov II, Shtil AA, Betzel C, Mironov AS, Mikhailov AM. X-ray structure of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil and molecular modelling of the complex of 5-fluorouracil with uridine phosphorylase from Vibrio cholerae. Acta Crystallogr D Biol Crystallogr. 2012 Aug;68(Pt 8):968-74. Epub 2012 Jul 17. PMID:22868762 doi:http://dx.doi.org/10.1107/S090744491201815X
