5hn1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Interleukin-37== | |
| - | + | <StructureSection load='5hn1' size='340' side='right' caption='[[5hn1]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hn1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HN1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hn1 OCA], [http://pdbe.org/5hn1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hn1 RCSB], [http://www.ebi.ac.uk/pdbsum/5hn1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hn1 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IL37_HUMAN IL37_HUMAN]] Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.<ref>PMID:18390730</ref> <ref>PMID:20935647</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ellisdon, A M]] | ||
| + | [[Category: Nold, M F]] | ||
| + | [[Category: Nold-Petry, C A]] | ||
| + | [[Category: Whisstock, J C]] | ||
| + | [[Category: Cytokine]] | ||
| + | [[Category: Interleukin-1 cytokine inflammation interleukin-18]] | ||
Revision as of 01:32, 11 March 2017
Crystal structure of Interleukin-37
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