This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5kzq
From Proteopedia
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Metabotropic Glutamate Receptor in complex with antagonist (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid== | |
| - | + | <StructureSection load='5kzq' size='340' side='right' caption='[[5kzq]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5kzq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KZQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6YS:(1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-AZANYL-3-[[3,4-BIS(FLUORANYL)PHENYL]SULFANYLMETHYL]-4-OXIDANYL-BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC+ACID'>6YS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kzn|5kzn]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kzq OCA], [http://pdbe.org/5kzq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kzq RCSB], [http://www.ebi.ac.uk/pdbsum/5kzq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kzq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Antonysamy, S]] | ||
| + | [[Category: Atwell, S]] | ||
| + | [[Category: Barberis, M]] | ||
| + | [[Category: Bedwell, D]] | ||
| + | [[Category: Blanco, M J]] | ||
| + | [[Category: Bradley, C]] | ||
| + | [[Category: Britton, T]] | ||
| + | [[Category: Bures, M]] | ||
| + | [[Category: Carpintero, M]] | ||
| + | [[Category: Catlow, J]] | ||
| + | [[Category: Chappell, M D]] | ||
| + | [[Category: Condon, B]] | ||
| + | [[Category: Conners, K]] | ||
| + | [[Category: Diego, J E.de]] | ||
| + | [[Category: Dressman, B A]] | ||
| + | [[Category: Erickson, J A]] | ||
| + | [[Category: Fivush, A M]] | ||
| + | [[Category: Garcia-Cerrada, S]] | ||
| + | [[Category: Groshong, C]] | ||
| + | [[Category: Heinz, B A]] | ||
| + | [[Category: Jaramillo, C]] | ||
| + | [[Category: Koss, J W]] | ||
| + | [[Category: Li, R]] | ||
| + | [[Category: Li, X]] | ||
| + | [[Category: MacEwan, I]] | ||
| + | [[Category: Matt, J]] | ||
| + | [[Category: Mayhugh, D]] | ||
| + | [[Category: Mitch, C H]] | ||
| + | [[Category: Monn, J A]] | ||
| + | [[Category: Ornstein, P]] | ||
| + | [[Category: Overshiner, C]] | ||
| + | [[Category: Quimby, S J]] | ||
| + | [[Category: Schkeryantz, J M]] | ||
| + | [[Category: Seidel, W]] | ||
| + | [[Category: Smith, S C]] | ||
| + | [[Category: Soriano, J F]] | ||
| + | [[Category: Swanson, S]] | ||
| + | [[Category: Tripp, A E]] | ||
| + | [[Category: Tromiczak, E G]] | ||
| + | [[Category: Vetman, T]] | ||
| + | [[Category: Wafford, K A]] | ||
| + | [[Category: Wang, J]] | ||
| + | [[Category: Wang, X S]] | ||
| + | [[Category: Wasserman, S R]] | ||
| + | [[Category: Witkin, J M]] | ||
| + | [[Category: Zhang, A]] | ||
| + | [[Category: Antagonist]] | ||
| + | [[Category: Antidepressent]] | ||
| + | [[Category: Mglur2]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 16:25, 2 January 2017
Metabotropic Glutamate Receptor in complex with antagonist (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
| |||||||||||
Categories: Antonysamy, S | Atwell, S | Barberis, M | Bedwell, D | Blanco, M J | Bradley, C | Britton, T | Bures, M | Carpintero, M | Catlow, J | Chappell, M D | Condon, B | Conners, K | Diego, J E.de | Dressman, B A | Erickson, J A | Fivush, A M | Garcia-Cerrada, S | Groshong, C | Heinz, B A | Jaramillo, C | Koss, J W | Li, R | Li, X | MacEwan, I | Matt, J | Mayhugh, D | Mitch, C H | Monn, J A | Ornstein, P | Overshiner, C | Quimby, S J | Schkeryantz, J M | Seidel, W | Smith, S C | Soriano, J F | Swanson, S | Tripp, A E | Tromiczak, E G | Vetman, T | Wafford, K A | Wang, J | Wang, X S | Wasserman, S R | Witkin, J M | Zhang, A | Antagonist | Antidepressent | Mglur2 | Signaling protein
