1q47
From Proteopedia
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'''Structure of the Semaphorin 3A Receptor-Binding Module''' | '''Structure of the Semaphorin 3A Receptor-Binding Module''' | ||
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[[Category: Puschel, A.]] | [[Category: Puschel, A.]] | ||
[[Category: Rajashankar, K R.]] | [[Category: Rajashankar, K R.]] | ||
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Revision as of 02:50, 3 May 2008
Structure of the Semaphorin 3A Receptor-Binding Module
Overview
The semaphorins are a large group of extracellular proteins involved in a variety of processes during development, including neuronal migration and axon guidance. Their distinctive feature is a conserved 500 amino acid semaphorin domain, a ligand-receptor interaction module also present in plexins and scatter-factor receptors. We report the crystal structure of a secreted 65 kDa form of Semaphorin-3A (Sema3A), containing the full semaphorin domain. Unexpectedly, the semaphorin fold is a variation of the beta propeller topology. Analysis of the Sema3A structure and structure-based mutagenesis data identify the neuropilin binding site and suggest a potential plexin interaction site. Based on the structure, we present a model for the initiation of semaphorin signaling and discuss potential similarities with the signaling mechanisms of other beta propeller cell surface receptors, such as integrins and the LDL receptor.
About this Structure
1Q47 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of the semaphorin-3A receptor binding module., Antipenko A, Himanen JP, van Leyen K, Nardi-Dei V, Lesniak J, Barton WA, Rajashankar KR, Lu M, Hoemme C, Puschel AW, Nikolov DB, Neuron. 2003 Aug 14;39(4):589-98. PMID:12925274 Page seeded by OCA on Sat May 3 05:50:58 2008
