1q56

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[[Image:1q56.jpg|left|200px]]
[[Image:1q56.jpg|left|200px]]
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{{Structure
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|PDB= 1q56 |SIZE=350|CAPTION= <scene name='initialview01'>1q56</scene>
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The line below this paragraph, containing "STRUCTURE_1q56", creates the "Structure Box" on the page.
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|GENE= AGRN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])
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{{STRUCTURE_1q56| PDB=1q56 | SCENE= }}
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|RELATEDENTRY=[[1pz7|1pz7]], [[1pz8|1pz8]], [[1pz9|1pz9]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q56 OCA], [http://www.ebi.ac.uk/pdbsum/1q56 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q56 RCSB]</span>
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'''NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state'''
'''NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state'''
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[[Category: Schulthess, T.]]
[[Category: Schulthess, T.]]
[[Category: Stetefeld, J.]]
[[Category: Stetefeld, J.]]
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[[Category: achr aggregation]]
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[[Category: Achr aggregation]]
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[[Category: ca2+ regulation]]
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[[Category: Ca2+ regulation]]
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[[Category: conformational flexibility]]
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[[Category: Conformational flexibility]]
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[[Category: laminin-g like domain]]
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[[Category: Laminin-g like domain]]
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[[Category: mrna splicing]]
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[[Category: Mrna splicing]]
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[[Category: musk activation]]
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[[Category: Musk activation]]
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[[Category: nmj synapse]]
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[[Category: Nmj synapse]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:52:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:08:56 2008''
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Revision as of 02:52, 3 May 2008

Image:1q56.jpg

Template:STRUCTURE 1q56

NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state


Overview

The aggregation of acetylcholine receptors on postsynaptic membranes is a key step in neuromuscular junction development. This process depends on alternatively spliced forms of the proteoglycan agrin with "B-inserts" of 8, 11, or 19 residues in the protein's globular C-terminal domain, G3. Structures of the neural B8 and B11 forms of agrin-G3 were determined by X-ray crystallography. The structure of G3-B0, which lacks inserts, was determined by NMR. The agrin-G3 domain adopts a beta jellyroll fold. The B insert site is flanked by four loops on one edge of the beta sandwich. The loops form a surface that corresponds to a versatile interaction interface in the family of structurally related LNS proteins. NMR and X-ray data indicate that this interaction interface is flexible in agrin-G3 and that flexibility is reduced by Ca(2+) binding. The plasticity of the interaction interface could enable different splice forms of agrin to select between multiple binding partners.

About this Structure

1Q56 is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Modulation of agrin function by alternative splicing and Ca2+ binding., Stetefeld J, Alexandrescu AT, Maciejewski MW, Jenny M, Rathgeb-Szabo K, Schulthess T, Landwehr R, Frank S, Ruegg MA, Kammerer RA, Structure. 2004 Mar;12(3):503-15. PMID:15016366 Page seeded by OCA on Sat May 3 05:52:43 2008

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