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1q5z

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[[Image:1q5z.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1q5z", creates the "Structure Box" on the page.
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|GENE= SipA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium])
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{{STRUCTURE_1q5z| PDB=1q5z | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5z OCA], [http://www.ebi.ac.uk/pdbsum/1q5z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q5z RCSB]</span>
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'''Crystal Structure of the C-terminal Actin Binding Domain of Salmonella Invasion Protein A (SipA)'''
'''Crystal Structure of the C-terminal Actin Binding Domain of Salmonella Invasion Protein A (SipA)'''
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[[Category: Stebbins, C E.]]
[[Category: Stebbins, C E.]]
[[Category: VanLoock, M S.]]
[[Category: VanLoock, M S.]]
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[[Category: cell invasion]]
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[[Category: Cell invasion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:54:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:09:15 2008''
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Revision as of 02:54, 3 May 2008

Image:1q5z.jpg

Template:STRUCTURE 1q5z

Crystal Structure of the C-terminal Actin Binding Domain of Salmonella Invasion Protein A (SipA)


Overview

Like many bacterial pathogens, Salmonella spp. use a type III secretion system to inject virulence proteins into host cells. The Salmonella invasion protein A (SipA) binds host actin, enhances its polymerization near adherent extracellular bacteria, and contributes to cytoskeletal rearrangements that internalize the pathogen. By combining x-ray crystallography of SipA with electron microscopy and image analysis of SipA-actin filaments, we show that SipA functions as a "molecular staple," in which a globular domain and two nonglobular "arms" mechanically stabilize the filament by tethering actin subunits in opposing strands. Deletion analysis of the tethering arms provides strong support for this model.

About this Structure

1Q5Z is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Salmonella SipA polymerizes actin by stapling filaments with nonglobular protein arms., Lilic M, Galkin VE, Orlova A, VanLoock MS, Egelman EH, Stebbins CE, Science. 2003 Sep 26;301(5641):1918-21. PMID:14512630 Page seeded by OCA on Sat May 3 05:54:26 2008

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