1q8h
From Proteopedia
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'''Crystal structure of porcine osteocalcin''' | '''Crystal structure of porcine osteocalcin''' | ||
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[[Category: Sicheri, F.]] | [[Category: Sicheri, F.]] | ||
[[Category: Yang, D S.]] | [[Category: Yang, D S.]] | ||
| - | [[Category: | + | [[Category: Bone gla protein]] |
| - | [[Category: | + | [[Category: Calcium binding protein]] |
| - | [[Category: | + | [[Category: Helix-turn-helix-turn-helix]] |
| - | [[Category: | + | [[Category: Hydroxyapatite crystal surface binding protein]] |
| - | [[Category: | + | [[Category: Paper-clip]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:59:45 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 02:59, 3 May 2008
Crystal structure of porcine osteocalcin
Overview
Osteocalcin is the most abundant noncollagenous protein in bone, and its concentration in serum is closely linked to bone metabolism and serves as a biological marker for the clinical assessment of bone disease. Although its precise mechanism of action is unclear, osteocalcin influences bone mineralization, in part through its ability to bind with high affinity to the mineral component of bone, hydroxyapatite. In addition to binding to hydroxyapatite, osteocalcin functions in cell signalling and the recruitment of osteoclasts and osteoblasts, which have active roles in bone resorption and deposition, respectively. Here we present the X-ray crystal structure of porcine osteocalcin at 2.0 A resolution, which reveals a negatively charged protein surface that coordinates five calcium ions in a spatial orientation that is complementary to calcium ions in a hydroxyapatite crystal lattice. On the basis of our findings, we propose a model of osteocalcin binding to hydroxyapatite and draw parallels with other proteins that engage crystal lattices.
About this Structure
1Q8H is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.
Reference
Bone recognition mechanism of porcine osteocalcin from crystal structure., Hoang QQ, Sicheri F, Howard AJ, Yang DS, Nature. 2003 Oct 30;425(6961):977-80. PMID:14586470 Page seeded by OCA on Sat May 3 05:59:45 2008
