5tdc

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'''Unreleased structure'''
 
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The entry 5tdc is ON HOLD until Paper Publication
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==Crystal structure of the human UBR-box domain from UBR1 in complex with monomethylated arginine peptide.==
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<StructureSection load='5tdc' size='340' side='right' caption='[[5tdc]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5tdc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TDC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TDC FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NMM:(2S)-2-AMINO-5-[(N-METHYLCARBAMIMIDOYL)AMINO]PENTANOIC+ACID'>NMM</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5tda|5tda]], [[5tdb|5tdb]], [[5tdd|5tdd]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tdc OCA], [http://pdbe.org/5tdc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tdc RCSB], [http://www.ebi.ac.uk/pdbsum/5tdc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tdc ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/UBR1_HUMAN UBR1_HUMAN]] Johanson-Blizzard syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/UBR1_HUMAN UBR1_HUMAN]] E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.<ref>PMID:15548684</ref> <ref>PMID:16311597</ref> <ref>PMID:20298436</ref> <ref>PMID:20835242</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Gehring, K]]
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[[Category: Kozlov, G]]
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[[Category: Matta-Camacho, E]]
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[[Category: Munoz-Escobar, J]]
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[[Category: Ligase]]
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[[Category: Monomethylated arginine]]
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[[Category: N-degron]]
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[[Category: N-end rule]]
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[[Category: Ubr-box]]

Revision as of 16:45, 22 March 2017

Crystal structure of the human UBR-box domain from UBR1 in complex with monomethylated arginine peptide.

5tdc, resolution 1.61Å

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