5tpz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in apo closed state== | |
| - | + | <StructureSection load='5tpz' size='340' side='right' caption='[[5tpz]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tpz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TPZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tpz OCA], [http://pdbe.org/5tpz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tpz RCSB], [http://www.ebi.ac.uk/pdbsum/5tpz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tpz ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NMDE2_RAT NMDE2_RAT]] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Furukawa, H]] | ||
| + | [[Category: Karakas, E]] | ||
| + | [[Category: Romero-Hernandez, A]] | ||
| + | [[Category: Simorwski, N]] | ||
| + | [[Category: Allosteric modulation]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Nmda receptor]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 19:21, 15 December 2016
Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in apo closed state
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