1q9o
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1q9o.jpg|left|200px]] | [[Image:1q9o.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1q9o", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1q9o| PDB=1q9o | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''S45-18 Fab Unliganded''' | '''S45-18 Fab Unliganded''' | ||
| Line 19: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q9O OCA]. | |
==Reference== | ==Reference== | ||
Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14625588 14625588] | Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14625588 14625588] | ||
| - | [[Category: Mus musculus]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Brade, H.]] | [[Category: Brade, H.]] | ||
[[Category: Brade, L.]] | [[Category: Brade, L.]] | ||
| Line 32: | Line 27: | ||
[[Category: Nguyen, H P.]] | [[Category: Nguyen, H P.]] | ||
[[Category: Seto, N O.]] | [[Category: Seto, N O.]] | ||
| - | [[Category: | + | [[Category: Anti-carbohydrate]] |
| - | [[Category: | + | [[Category: Anti-lp]] |
| - | [[Category: | + | [[Category: Antibody]] |
| - | [[Category: | + | [[Category: Antigen-binding fragment]] |
| - | [[Category: | + | [[Category: Fab]] |
| - | [[Category: | + | [[Category: Immunoglobulin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:02:29 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 03:02, 3 May 2008
S45-18 Fab Unliganded
Overview
High-resolution structures reveal how a germline antibody can recognize a range of clinically relevant carbohydrate epitopes. The germline response to a carbohydrate immunogen can be critical to survivability, with selection for antibody gene segments that both confer protection against common pathogens and retain the flexibility to adapt to new disease organisms. We show here that antibody S25-2 binds several distinct inner-core epitopes of bacterial lipopolysaccharides (LPSs) by linking an inherited monosaccharide residue binding site with a subset of complementarity-determining regions (CDRs) of limited flexibility positioned to recognize the remainder of an array of different epitopes. This strategy allows germline antibodies to adapt to different epitopes while minimizing entropic penalties associated with the immobilization of labile CDRs upon binding of antigen, and provides insight into the link between the genetic origin of individual CDRs and their respective roles in antigen recognition.
About this Structure
Full crystallographic information is available from OCA.
Reference
Germline antibody recognition of distinct carbohydrate epitopes., Nguyen HP, Seto NO, MacKenzie CR, Brade L, Kosma P, Brade H, Evans SV, Nat Struct Biol. 2003 Dec;10(12):1019-25. Epub 2003 Nov 16. PMID:14625588 Page seeded by OCA on Sat May 3 06:02:29 2008
