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1qa6

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[[Image:1qa6.gif|left|200px]]
[[Image:1qa6.gif|left|200px]]
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{{Structure
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OS:OSMIUM+ION'>OS</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1qa6| PDB=1qa6 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qa6 OCA], [http://www.ebi.ac.uk/pdbsum/1qa6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qa6 RCSB]</span>
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'''CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX'''
'''CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX'''
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[[Category: Gittis, A G.]]
[[Category: Gittis, A G.]]
[[Category: Lattman, E E.]]
[[Category: Lattman, E E.]]
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[[Category: antibiotic binding]]
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[[Category: Antibiotic binding]]
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[[Category: minor groove binding]]
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[[Category: Minor groove binding]]
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[[Category: ribosomal rna]]
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[[Category: Ribosomal rna]]
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[[Category: tertiary structur,e rna-protein interaction]]
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[[Category: Tertiary structur,e rna-protein interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:03:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:10:54 2008''
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Revision as of 03:03, 3 May 2008

Image:1qa6.gif

Template:STRUCTURE 1qa6

CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX


Overview

The structure of a highly conserved complex between a 58-nucleotide domain of large subunit ribosomal RNA and the RNA-binding domain of ribosomal protein L11 has been solved at 2.8 angstrom resolution. It reveals a precisely folded RNA structure that is stabilized by extensive tertiary contacts and contains an unusually large core of stacked bases. A bulge loop base from one hairpin of the RNA is intercalated into the distorted major groove of another helix; the protein locks this tertiary interaction into place by binding to the intercalated base from the minor groove side. This direct interaction with a key ribosomal RNA tertiary interaction suggests that part of the role of L11 is to stabilize an unusual RNA fold within the ribosome.

About this Structure

1QA6 is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a conserved ribosomal protein-RNA complex., Conn GL, Draper DE, Lattman EE, Gittis AG, Science. 1999 May 14;284(5417):1171-4. PMID:10325228 Page seeded by OCA on Sat May 3 06:03:33 2008

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