1qd9
From Proteopedia
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'''Bacillus subtilis YABJ''' | '''Bacillus subtilis YABJ''' | ||
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[[Category: Smith, J L.]] | [[Category: Smith, J L.]] | ||
[[Category: Zalkin, H.]] | [[Category: Zalkin, H.]] | ||
| - | [[Category: | + | [[Category: Gene regulation]] |
| - | [[Category: | + | [[Category: Perchloric acid soluble protein]] |
| - | [[Category: | + | [[Category: Purine regulation]] |
| - | [[Category: | + | [[Category: Yjgf/yer057c family]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:09:10 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 03:09, 3 May 2008
Bacillus subtilis YABJ
Overview
The yabJ gene in Bacillus subtilis is required for adenine-mediated repression of purine biosynthetic genes in vivo and codes for an acid-soluble, 14-kDa protein. The molecular mechanism of YabJ is unknown. YabJ is a member of a large, widely distributed family of proteins of unknown biochemical function. The 1.7-A crystal structure of YabJ reveals a trimeric organization with extensive buried hydrophobic surface and an internal water-filled cavity. The most important finding in the structure is a deep, narrow cleft between subunits lined with nine side chains that are invariant among the 25 most similar homologs. This conserved site is proposed to be a binding or catalytic site for a ligand or substrate that is common to YabJ and other members of the YER057c/YjgF/UK114 family of proteins.
About this Structure
1QD9 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family., Sinha S, Rappu P, Lange SC, Mantsala P, Zalkin H, Smith JL, Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13074-9. PMID:10557275 Page seeded by OCA on Sat May 3 06:09:10 2008
