1qf8

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[[Image:1qf8.jpg|left|200px]]
[[Image:1qf8.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1qf8 |SIZE=350|CAPTION= <scene name='initialview01'>1qf8</scene>, resolution 1.74&Aring;
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The line below this paragraph, containing "STRUCTURE_1qf8", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1qf8| PDB=1qf8 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qf8 OCA], [http://www.ebi.ac.uk/pdbsum/1qf8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qf8 RCSB]</span>
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}}
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'''TRUNCATED FORM OF CASEIN KINASE II BETA SUBUNIT (2-182) FROM HOMO SAPIENS'''
'''TRUNCATED FORM OF CASEIN KINASE II BETA SUBUNIT (2-182) FROM HOMO SAPIENS'''
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[[Category: Leroy, D.]]
[[Category: Leroy, D.]]
[[Category: Nueda, A.]]
[[Category: Nueda, A.]]
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[[Category: casein kinase beta subunit (1-182)]]
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[[Category: Ser/thr protein kinase]]
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[[Category: ser/thr protein kinase]]
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[[Category: Zn finger]]
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[[Category: zn finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:11:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:12:37 2008''
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Revision as of 03:11, 3 May 2008

Image:1qf8.jpg

Template:STRUCTURE 1qf8

TRUNCATED FORM OF CASEIN KINASE II BETA SUBUNIT (2-182) FROM HOMO SAPIENS


Overview

Protein kinase CK2 is a tetramer composed of two alpha catalytic subunits and two beta regulatory subunits. The structure of a C-terminal truncated form of the human beta subunit has been determined by X-ray crystallography to 1.7 A resolution. One dimer is observed in the asymmetric unit of the crystal. The most striking feature of the structure is the presence of a zinc finger mediating the dimerization. The monomer structure consists of two domains, one entirely alpha-helical and one including the zinc finger. The dimer has a crescent shape holding a highly acidic region at both ends. We propose that this acidic region is involved in the interactions with the polyamines and/or catalytic subunits. Interestingly, conserved amino acid residues among beta subunit sequences are clustered along one linear ridge that wraps around the entire dimer. This feature suggests that protein partners may interact with the dimer through a stretch of residues in an extended conformation.

About this Structure

1QF8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization., Chantalat L, Leroy D, Filhol O, Nueda A, Benitez MJ, Chambaz EM, Cochet C, Dideberg O, EMBO J. 1999 Jun 1;18(11):2930-40. PMID:10357806 Page seeded by OCA on Sat May 3 06:11:40 2008

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