1qf4

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[[Image:1qf4.jpg|left|200px]]
[[Image:1qf4.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1qf4 |SIZE=350|CAPTION= <scene name='initialview01'>1qf4</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1qf4", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RPD:(C8-R)-HYDANTOCIDIN+5&#39;-PHOSPHATE'>RPD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1qf4| PDB=1qf4 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qf4 OCA], [http://www.ebi.ac.uk/pdbsum/1qf4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qf4 RCSB]</span>
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}}
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'''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE'''
'''DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE'''
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[[Category: Prade, L.]]
[[Category: Prade, L.]]
[[Category: Sanceau, J Y.]]
[[Category: Sanceau, J Y.]]
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[[Category: gtp-binding]]
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[[Category: Gtp-binding]]
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[[Category: gtp-hydrolysing enzyme]]
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[[Category: Gtp-hydrolysing enzyme]]
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[[Category: purine biosynthesis]]
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[[Category: Purine biosynthesis]]
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[[Category: synthetase]]
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[[Category: Synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:11:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:12:36 2008''
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Revision as of 03:11, 3 May 2008

Image:1qf4.jpg

Template:STRUCTURE 1qf4

DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE


Overview

Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.

About this Structure

1QF4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:10556888 Page seeded by OCA on Sat May 3 06:11:22 2008

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OCA

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