1qfs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1qfs.gif|left|200px]]
[[Image:1qfs.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1qfs |SIZE=350|CAPTION= <scene name='initialview01'>1qfs</scene>, resolution 2.0&Aring;
+
The line below this paragraph, containing "STRUCTURE_1qfs", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ZPR:N-BENZYLOXYCARBONYL-L-PROLYL-L-PROLINAL'>ZPR</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Prolyl_oligopeptidase Prolyl oligopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.26 3.4.21.26] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1qfs| PDB=1qfs | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qfs OCA], [http://www.ebi.ac.uk/pdbsum/1qfs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qfs RCSB]</span>
+
-
}}
+
'''PROLYL OLIGOPEPTIDASE FROM PORCINE MUSCLE WITH COVALENTLY BOUND INHIBITOR Z-PRO-PROLINAL'''
'''PROLYL OLIGOPEPTIDASE FROM PORCINE MUSCLE WITH COVALENTLY BOUND INHIBITOR Z-PRO-PROLINAL'''
Line 27: Line 24:
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Fulop, V.]]
[[Category: Fulop, V.]]
-
[[Category: alpha/beta-hydrolase]]
+
[[Category: Alpha/beta-hydrolase]]
-
[[Category: amnesia]]
+
[[Category: Amnesia]]
-
[[Category: beta-propeller]]
+
[[Category: Beta-propeller]]
-
[[Category: prolyl oligopeptidase]]
+
[[Category: Prolyl oligopeptidase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:12:55 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:12:59 2008''
+

Revision as of 03:12, 3 May 2008

Image:1qfs.gif

Template:STRUCTURE 1qfs

PROLYL OLIGOPEPTIDASE FROM PORCINE MUSCLE WITH COVALENTLY BOUND INHIBITOR Z-PRO-PROLINAL


Overview

Prolyl oligopeptidase is a large cytosolic enzyme that belongs to a new class of serine peptidases. The enzyme is involved in the maturation and degradation of peptide hormones and neuropeptides, which relate to the induction of amnesia. The 1.4 A resolution crystal structure is presented here. The enzyme contains a peptidase domain with an alpha/beta hydrolase fold, and its catalytic triad (Ser554, His680, Asp641) is covered by the central tunnel of an unusual beta propeller. This domain makes prolyl oligopeptidase an oligopeptidase by excluding large structured peptides from the active site. In this way, the propeller protects larger peptides and proteins from proteolysis in the cytosol. The structure is also obtained with a transition state inhibitor, which may facilitate drug design to treat memory disorders.

About this Structure

1QFS is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis., Fulop V, Bocskei Z, Polgar L, Cell. 1998 Jul 24;94(2):161-70. PMID:9695945 Page seeded by OCA on Sat May 3 06:12:55 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qfs"
Personal tools