1qgh

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[[Image:1qgh.gif|left|200px]]
[[Image:1qgh.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1qgh |SIZE=350|CAPTION= <scene name='initialview01'>1qgh</scene>, resolution 2.35&Aring;
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The line below this paragraph, containing "STRUCTURE_1qgh", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ASA:Fe-Binding+Site'>ASA</scene>, <scene name='pdbsite=ASB:Fe-Binding+Site'>ASB</scene>, <scene name='pdbsite=ASC:Fe-Binding+Site'>ASC</scene>, <scene name='pdbsite=ASD:Fe-Binding+Site'>ASD</scene>, <scene name='pdbsite=ASE:Fe-Binding+Site'>ASE</scene>, <scene name='pdbsite=ASF:Fe-Binding+Site'>ASF</scene>, <scene name='pdbsite=ASG:Fe-Binding+Site'>ASG</scene>, <scene name='pdbsite=ASH:Fe-Binding+Site'>ASH</scene>, <scene name='pdbsite=ASI:Fe-Binding+Site'>ASI</scene>, <scene name='pdbsite=ASJ:Fe-Binding+Site'>ASJ</scene>, <scene name='pdbsite=ASK:Fe-Binding+Site'>ASK</scene> and <scene name='pdbsite=ASL:Fe-Binding+Site'>ASL</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1qgh| PDB=1qgh | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qgh OCA], [http://www.ebi.ac.uk/pdbsum/1qgh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qgh RCSB]</span>
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}}
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'''THE X-RAY STRUCTURE OF THE UNUSUAL DODECAMERIC FERRITIN FROM LISTERIA INNOCUA, REVEALS A NOVEL INTERSUBUNIT IRON BINDING SITE.'''
'''THE X-RAY STRUCTURE OF THE UNUSUAL DODECAMERIC FERRITIN FROM LISTERIA INNOCUA, REVEALS A NOVEL INTERSUBUNIT IRON BINDING SITE.'''
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[[Category: Stefanini, S.]]
[[Category: Stefanini, S.]]
[[Category: Tsernoglou, D.]]
[[Category: Tsernoglou, D.]]
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[[Category: ferritin]]
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[[Category: Ferritin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:14:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:13:09 2008''
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Revision as of 03:14, 3 May 2008

Image:1qgh.gif

Template:STRUCTURE 1qgh

THE X-RAY STRUCTURE OF THE UNUSUAL DODECAMERIC FERRITIN FROM LISTERIA INNOCUA, REVEALS A NOVEL INTERSUBUNIT IRON BINDING SITE.


Overview

Ferritin is characterized by a highly conserved architecture that comprises 24 subunits assembled into a spherical cage with 432 symmetry. The only known exception is the dodecameric ferritin from Listeria innocua. The structure of Listeria ferritin has been determined to a resolution of 2.35 A by molecular replacement, using as a search model the structure of Dps from Escherichia coli. The Listeria 12-mer is endowed with 23 symmetry and displays the functionally relevant structural features of the ferritin 24-mer, namely the negatively charged channels along the three-fold symmetry axes that serve for iron entry into the cavity and a negatively charged internal cavity for iron deposition. The electron density map shows 12 iron ions on the inner surface of the hollow core, at the interface between monomers related by two-fold axes. Analysis of the nature and stereochemistry of the iron-binding ligands reveals strong similarities with known ferroxidase sites. The L. innocua ferritin site, however, is the first described so far that has ligands belonging to two different subunits and is not contained within a four-helix bundle.

About this Structure

1QGH is a Single protein structure of sequence from Listeria innocua. Full crystallographic information is available from OCA.

Reference

The dodecameric ferritin from Listeria innocua contains a novel intersubunit iron-binding site., Ilari A, Stefanini S, Chiancone E, Tsernoglou D, Nat Struct Biol. 2000 Jan;7(1):38-43. PMID:10625425 Page seeded by OCA on Sat May 3 06:14:28 2008

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