1qjl
From Proteopedia
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'''METALLOTHIONEIN MTA FROM SEA URCHIN (BETA DOMAIN)''' | '''METALLOTHIONEIN MTA FROM SEA URCHIN (BETA DOMAIN)''' | ||
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[[Category: Wider, G.]] | [[Category: Wider, G.]] | ||
[[Category: Wuthrich, K.]] | [[Category: Wuthrich, K.]] | ||
| - | [[Category: | + | [[Category: Detoxification]] |
| - | [[Category: | + | [[Category: Metal-binding]] |
| - | [[Category: | + | [[Category: Metallothionein]] |
| - | [[Category: | + | [[Category: Radical scavenger]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:21:09 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 03:21, 3 May 2008
METALLOTHIONEIN MTA FROM SEA URCHIN (BETA DOMAIN)
Overview
The three-dimensional structure of [(113)Cd7]-metallothionein-A (MTA) of the sea urchin Strongylocentrotus purpuratus was determined by homonuclear(1)H NMR experiments and heteronuclear [(1)H, (113)Cd]-correlation spectroscopy. MTA is composed of two globular domains, an N-terminal four-metal domain of the amino acid residues 1 to 36 and a Cd4Cys11cluster, and a C-terminal three-metal domain including the amino acid residues 37 to 65 and a Cd3Cys9cluster. The structure resembles the known mammalian and crustacean metallothioneins, but has a significantly different connectivity pattern of the Cys-metal co-ordination bonds and concomitantly contains novel local folds of some polypeptide backbone segments. These differences can be related to variations of the Cys sequence positions and thus emphasize the special role of the cysteine residues in defining the structure of metallothioneins, both on the level of the domain architecture and the topology of the metal-thiolate clusters.
About this Structure
1QJL is a Single protein structure of sequence from Strongylocentrotus purpuratus. Full crystallographic information is available from OCA.
Reference
NMR structure of the sea urchin (Strongylocentrotus purpuratus) metallothionein MTA., Riek R, Precheur B, Wang Y, Mackay EA, Wider G, Guntert P, Liu A, Kagi JH, Wuthrich K, J Mol Biol. 1999 Aug 13;291(2):417-28. PMID:10438629 Page seeded by OCA on Sat May 3 06:21:09 2008
