We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1qmz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1qmz.jpg|left|200px]]
[[Image:1qmz.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1qmz |SIZE=350|CAPTION= <scene name='initialview01'>1qmz</scene>, resolution 2.2&Aring;
+
The line below this paragraph, containing "STRUCTURE_1qmz", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1qmz| PDB=1qmz | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qmz OCA], [http://www.ebi.ac.uk/pdbsum/1qmz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qmz RCSB]</span>
+
-
}}
+
'''PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX'''
'''PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX'''
Line 29: Line 26:
[[Category: Johnson, L N.]]
[[Category: Johnson, L N.]]
[[Category: Noble, M E.M.]]
[[Category: Noble, M E.M.]]
-
[[Category: cdk]]
+
[[Category: Cdk]]
-
[[Category: complex (protein kinase/cyclin)]]
+
[[Category: Cyclin]]
-
[[Category: cyclin]]
+
[[Category: Phosphorylation]]
-
[[Category: phosphorylation]]
+
[[Category: Substrate complex]]
-
[[Category: substrate complex]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:28:02 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:16:04 2008''
+

Revision as of 03:28, 3 May 2008

Image:1qmz.jpg

Template:STRUCTURE 1qmz

PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX


Overview

Progression through the eukaryotic cell cycle is driven by the orderly activation of cyclin-dependent kinases (CDKs). For activity, CDKs require association with a cyclin and phosphorylation by a separate protein kinase at a conserved threonine residue (T160 in CDK2). Here we present the structure of a complex consisting of phosphorylated CDK2 and cyclin A together with an optimal peptide substrate, HHASPRK. This structure provides an explanation for the specificity of CDK2 towards the proline that follows the phosphorylatable serine of the substrate peptide, and the requirement for the basic residue in the P+3 position of the substrate. We also present the structure of phosphorylated CDK2 plus cyclin A3 in complex with residues 658-668 from the CDK2 substrate p107. These residues include the RXL motif required to target p107 to cyclins. This structure explains the specificity of the RXL motif for cyclins.

About this Structure

1QMZ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases., Brown NR, Noble ME, Endicott JA, Johnson LN, Nat Cell Biol. 1999 Nov;1(7):438-43. PMID:10559988 Page seeded by OCA on Sat May 3 06:28:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qmz"
Personal tools