1qoy

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[[Image:1qoy.gif|left|200px]]
[[Image:1qoy.gif|left|200px]]
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{{Structure
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|PDB= 1qoy |SIZE=350|CAPTION= <scene name='initialview01'>1qoy</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1qoy", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= HLYE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_1qoy| PDB=1qoy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qoy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qoy OCA], [http://www.ebi.ac.uk/pdbsum/1qoy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qoy RCSB]</span>
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'''E.COLI HEMOLYSIN E (HLYE, CLYA, SHEA)'''
'''E.COLI HEMOLYSIN E (HLYE, CLYA, SHEA)'''
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[[Category: Stillman, T J.]]
[[Category: Stillman, T J.]]
[[Category: Wallace, A J.]]
[[Category: Wallace, A J.]]
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[[Category: cytolysin]]
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[[Category: Cytolysin]]
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[[Category: hemolysin]]
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[[Category: Hemolysin]]
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[[Category: membrane pore former]]
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[[Category: Membrane pore former]]
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[[Category: pore]]
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[[Category: Pore]]
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[[Category: toxin]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:32:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:16:54 2008''
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Revision as of 03:32, 3 May 2008

Image:1qoy.gif

Template:STRUCTURE 1qoy

E.COLI HEMOLYSIN E (HLYE, CLYA, SHEA)


Overview

Hemolysin E (HlyE) is a novel pore-forming toxin of Escherichia coli, Salmonella typhi, and Shigella flexneri. Here we report the X-ray crystal structure of the water-soluble form of E. coli HlyE at 2.0 A resolution and the visualization of the lipid-associated form of the toxin in projection at low resolution by electron microscopy. The crystal structure reveals HlyE to be the first member of a new family of toxin structures, consisting of an elaborated helical bundle some 100 A long. The electron micrographs show how HlyE oligomerizes in the presence of lipid to form transmembrane pores. Taken together, the data from these two structural techniques allow us to propose a simple model for the structure of the pore and for membrane interaction.

About this Structure

1QOY is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

E. coli hemolysin E (HlyE, ClyA, SheA): X-ray crystal structure of the toxin and observation of membrane pores by electron microscopy., Wallace AJ, Stillman TJ, Atkins A, Jamieson SJ, Bullough PA, Green J, Artymiuk PJ, Cell. 2000 Jan 21;100(2):265-76. PMID:10660049 Page seeded by OCA on Sat May 3 06:32:03 2008

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