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Uridine phosphorylase

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Line 41: Line 41:
**[[4r2x]] – SoUPP + sulfate – ''Shewanella oneidensis''<br />
**[[4r2x]] – SoUPP + sulfate – ''Shewanella oneidensis''<br />
**[[4yjk]] – SoUPP (mutant) + uracil <br />
**[[4yjk]] – SoUPP (mutant) + uracil <br />
 +
**[[5epu]] – VcUPP + cytosine <br />
*Uridine phosphorylase ternary complex
*Uridine phosphorylase ternary complex
Line 61: Line 62:
**[[3kvy]] – bUPP + sulfate + uracil <br />
**[[3kvy]] – bUPP + sulfate + uracil <br />
**[[3pns]] – VcUPP + sulfate + uracil <br />
**[[3pns]] – VcUPP + sulfate + uracil <br />
 +
**[[5lhv]] – VcUPP + sulfate + uridine <br />
 +
**[[5efo]], [[5lok]] – VcUPP + cytosine + cytidine <br />
**[[4mch]] – VfUPP + sulfate + hydroxyl naphthoic acid <br />
**[[4mch]] – VfUPP + sulfate + hydroxyl naphthoic acid <br />
**[[4mci]] – VfUPP + sulfate + DMSO <br />
**[[4mci]] – VfUPP + sulfate + DMSO <br />

Revision as of 21:19, 13 October 2017

Structure of uridine phosphorylase complex with fluorouracil, glycerol, ethylene glycol and K+ ion (purple) (PDB code 4e1v).

Drag the structure with the mouse to rotate

3D Structures of uridine phosphorylase

Updated on 13-October-2017

References

  1. ↑ Pizzorno G, Cao D, Leffert JJ, Russell RL, Zhang D, Handschumacher RE. Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update. Biochim Biophys Acta. 2002 Jul 18;1587(2-3):133-44. PMID:12084455
  2. ↑ Renck D, Santos AA Jr, Machado P, Petersen GO, Lopes TG, Santos DS, Campos MM, Basso LA. Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis. Invest New Drugs. 2014 Dec;32(6):1301-7. doi: 10.1007/s10637-014-0135-0. Epub, 2014 Jul 23. PMID:25052233 doi:http://dx.doi.org/10.1007/s10637-014-0135-0
  3. ↑ Lashkov AA, Sotnichenko SE, Prokofiev II, Gabdulkhakov AG, Agapov II, Shtil AA, Betzel C, Mironov AS, Mikhailov AM. X-ray structure of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil and molecular modelling of the complex of 5-fluorouracil with uridine phosphorylase from Vibrio cholerae. Acta Crystallogr D Biol Crystallogr. 2012 Aug;68(Pt 8):968-74. Epub 2012 Jul 17. PMID:22868762 doi:http://dx.doi.org/10.1107/S090744491201815X

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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