Villin
From Proteopedia
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<StructureSection load='2k6n' size='340' side='right' caption='Human supervillin headpiece, [[2k6n]]' scene='Villin/Cv/1' > | <StructureSection load='2k6n' size='340' side='right' caption='Human supervillin headpiece, [[2k6n]]' scene='Villin/Cv/1' > | ||
| + | == Function == | ||
* [[Villin]] (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>.<br /> | * [[Villin]] (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>.<br /> | ||
* '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin.<br /> | * '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin.<br /> | ||
* '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons.<br /> | * '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons.<br /> | ||
* '''Cytovillin (CVIL) or ezrin or villin-2''' serves as intermediate between plasma membrane and actin cytoskeleton. | * '''Cytovillin (CVIL) or ezrin or villin-2''' serves as intermediate between plasma membrane and actin cytoskeleton. | ||
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| + | == Relevance == | ||
| + | VIL immunohisochemistry is a reliable method for diagnosing microvillus inclusion disease (MVID)<ref>PMID:25517957</ref>. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Villin == | == 3D Structures of Villin == | ||
Revision as of 08:57, 13 December 2016
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3D Structures of Villin
Updated on 13-December-2016
References
- ↑ Friederich E, Vancompernolle K, Louvard D, Vandekerckhove J. Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. J Biol Chem. 1999 Sep 17;274(38):26751-60. PMID:10480879
- ↑ Shillingford NM, Calicchio ML, Teot LA, Boyd T, Kurek KC, Goldsmith JD, Bousvaros A, Perez-Atayde AR, Kozakewich HP. Villin immunohistochemistry is a reliable method for diagnosing microvillus inclusion disease. Am J Surg Pathol. 2015 Feb;39(2):245-50. doi: 10.1097/PAS.0000000000000355. PMID:25517957 doi:http://dx.doi.org/10.1097/PAS.0000000000000355
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