Wiskott-Aldrich syndrome protein

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== Disease ==
== Disease ==
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Mutations in WASP can cause Wiskott-Aldrich syndrome which is a rare inherited disease characterized by immune dysregulation<ref>PMID:18043243</ref>.
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Mutations in WASP can cause Wiskott-Aldrich syndrome which is a rare inherited disease characterized by immune disregulation<ref>PMID:18043243</ref>.
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== Relevance ==
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== Structural highlights ==
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</StructureSection>
</StructureSection>

Revision as of 10:20, 14 December 2016

Human WASP WH2 domain (pink) complex with α-actin (grey), DNAse I (green), ATP (stick model), Ca+2 and Mg+2 ions, glycerol and formic acid (PDB code 2a3z)

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3D Structures of Wiskott-Aldrich syndrome protein

Updated on 14-December-2016

References

  1. ↑ Westerberg LS, Dahlberg C, Baptista M, Moran CJ, Detre C, Keszei M, Eston MA, Alt FW, Terhorst C, Notarangelo LD, Snapper SB. Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood. 2012 Apr 26;119(17):3966-74. doi: 10.1182/blood-2010-09-308197. Epub 2012 , Mar 12. PMID:22411869 doi:http://dx.doi.org/10.1182/blood-2010-09-308197
  2. ↑ Notarangelo LD, Miao CH, Ochs HD. Wiskott-Aldrich syndrome. Curr Opin Hematol. 2008 Jan;15(1):30-6. PMID:18043243 doi:http://dx.doi.org/10.1097/MOH.0b013e3282f30448

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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