1qsg

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[[Image:1qsg.gif|left|200px]]
[[Image:1qsg.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1qsg |SIZE=350|CAPTION= <scene name='initialview01'>1qsg</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_1qsg", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1qsg| PDB=1qsg | SCENE= }}
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|RELATEDENTRY=[[1dfi|1DFI]], [[1dfg|1DFG]], [[1dfh|1DFH]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qsg OCA], [http://www.ebi.ac.uk/pdbsum/1qsg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qsg RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF ENOYL REDUCTASE INHIBITION BY TRICLOSAN'''
'''CRYSTAL STRUCTURE OF ENOYL REDUCTASE INHIBITION BY TRICLOSAN'''
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==Reference==
==Reference==
Structural basis and mechanism of enoyl reductase inhibition by triclosan., Stewart MJ, Parikh S, Xiao G, Tonge PJ, Kisker C, J Mol Biol. 1999 Jul 23;290(4):859-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10398587 10398587]
Structural basis and mechanism of enoyl reductase inhibition by triclosan., Stewart MJ, Parikh S, Xiao G, Tonge PJ, Kisker C, J Mol Biol. 1999 Jul 23;290(4):859-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10398587 10398587]
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[[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
 
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Tonge, P J.]]
[[Category: Tonge, P J.]]
[[Category: Xiao, G.]]
[[Category: Xiao, G.]]
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[[Category: enoyl reductase]]
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[[Category: Enoyl reductase]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:39:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:18:20 2008''
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Revision as of 03:39, 3 May 2008

Image:1qsg.gif

Template:STRUCTURE 1qsg

CRYSTAL STRUCTURE OF ENOYL REDUCTASE INHIBITION BY TRICLOSAN


Overview

The enoyl-acyl carrier protein reductase (ENR) is involved in bacterial fatty acid biosynthesis and is the target of the antibacterial diazaborine compounds and the front-line antituberculosis drug isoniazid. Recent studies suggest that ENR is also the target for the broad-spectrum biocide triclosan. The 1.75 A crystal structure of EnvM, the ENR from Escherichia coli, in complex with triclosan and NADH reveals that triclosan binds specifically to EnvM. These data provide a molecular mechanism for the antibacterial activity of triclosan and substantiate the hypothesis that its activity results from inhibition of a specific cellular target rather than non-specific disruption of the bacterial cell membrane. This has important implications for the emergence of drug-resistant bacteria, since triclosan is an additive in many personal care products such as toothpastes, mouthwashes and soaps. Based on this structure, rational design of triclosan derivatives is possible which might be effective against recently identified triclosan-resistant bacterial strains.

About this Structure

1QSG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis and mechanism of enoyl reductase inhibition by triclosan., Stewart MJ, Parikh S, Xiao G, Tonge PJ, Kisker C, J Mol Biol. 1999 Jul 23;290(4):859-65. PMID:10398587 Page seeded by OCA on Sat May 3 06:39:13 2008

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