This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5bx1
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of PRL-1 complex with compound analogy 3== | |
| - | + | <StructureSection load='5bx1' size='340' side='right' caption='[[5bx1]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5bx1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BX1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4XA:3-(5,6-DIMETHYL-2H-ISOINDOL-2-YL)-N-[(E)-FURAN-2-YLMETHYLIDENE]BENZOHYDRAZIDE'>4XA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zck|1zck]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bx1 OCA], [http://pdbe.org/5bx1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bx1 RCSB], [http://www.ebi.ac.uk/pdbsum/5bx1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bx1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TP4A1_HUMAN TP4A1_HUMAN]] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.<ref>PMID:12235145</ref> <ref>PMID:14643450</ref> <ref>PMID:12782572</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Protein-tyrosine-phosphatase]] | ||
[[Category: Bai, Y]] | [[Category: Bai, Y]] | ||
| + | [[Category: Liu, S]] | ||
[[Category: Zhang, Z]] | [[Category: Zhang, Z]] | ||
| - | [[Category: | + | [[Category: Detrimerizer]] |
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Interface]] | ||
| + | [[Category: Monomer]] | ||
| + | [[Category: Protein tyrosine phosphatase]] | ||
Revision as of 21:36, 22 December 2016
Crystal Structure of PRL-1 complex with compound analogy 3
| |||||||||||
