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5ml9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer F4, a specific binding protein which blocks IgG binding to the receptor.== | |
| - | + | <StructureSection load='5ml9' size='340' side='right' caption='[[5ml9]], [[Resolution|resolution]] 2.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ml9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ML9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ML9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ml9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ml9 OCA], [http://pdbe.org/5ml9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ml9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ml9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ml9 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/FCG3A_HUMAN FCG3A_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23006327</ref> <ref>PMID:8608639</ref> <ref>PMID:8609432</ref> <ref>PMID:8874200</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FCG3A_HUMAN FCG3A_HUMAN]] Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.<ref>PMID:21768335</ref> <ref>PMID:22023369</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Baxter, E W]] | ||
| + | [[Category: Fishwick, C W.G]] | ||
| + | [[Category: Foster, R J]] | ||
| + | [[Category: Goldman, A]] | ||
| + | [[Category: Harris, S A]] | ||
| + | [[Category: McPherson, M J]] | ||
| + | [[Category: Morgan, A W]] | ||
| + | [[Category: Nettleship, J E]] | ||
| + | [[Category: Owen, R L]] | ||
| + | [[Category: Owens, R J]] | ||
| + | [[Category: Robinson, J I]] | ||
| + | [[Category: Thomsen, M]] | ||
| + | [[Category: Tiede, C]] | ||
| + | [[Category: Tomlinson, D C]] | ||
| + | [[Category: Waterhouse, M P]] | ||
| + | [[Category: Win, S J]] | ||
| + | [[Category: Fc gamma receptor iiia affimer competitive inhibitor fcgr3a]] | ||
| + | [[Category: Immune system]] | ||
Revision as of 06:53, 13 December 2017
Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer F4, a specific binding protein which blocks IgG binding to the receptor.
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Categories: Baxter, E W | Fishwick, C W.G | Foster, R J | Goldman, A | Harris, S A | McPherson, M J | Morgan, A W | Nettleship, J E | Owen, R L | Owens, R J | Robinson, J I | Thomsen, M | Tiede, C | Tomlinson, D C | Waterhouse, M P | Win, S J | Fc gamma receptor iiia affimer competitive inhibitor fcgr3a | Immune system
