1qtf
From Proteopedia
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'''CRYSTAL STRUCTURE OF EXFOLIATIVE TOXIN B''' | '''CRYSTAL STRUCTURE OF EXFOLIATIVE TOXIN B''' | ||
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[[Category: Schlievert, P M.]] | [[Category: Schlievert, P M.]] | ||
[[Category: Vath, G M.]] | [[Category: Vath, G M.]] | ||
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| - | [[Category: | + | [[Category: Superantigen]] |
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Revision as of 03:41, 3 May 2008
CRYSTAL STRUCTURE OF EXFOLIATIVE TOXIN B
Overview
The exfoliative toxins (ETs) cause staphylococcal scalded skin syndrome, a disease characterized by specific separation of layers of the skin. Evidence suggests that the toxins act as serine proteases, though the specific substrate and mode of action are not known for certain. The crystal structure of exfoliative toxin A (ETA) was reported earlier and shown to be similar to that of the chymotrypsin-like serine proteases. Here, we report the 2.4 A resolution crystal structure of the other exfoliative toxin, ETB, which is 40% identical to ETA. The overall structures of ETA and ETB are similar including the positions of key residues within the active site. The structure of ETB supports the previous findings that the ETs are serine proteases that cleave substrates after glutamic acid residues. In this study we also discuss a number of structural differences including a large 14 residue loop insertion which may be a key feature involved in the differing biological properties of the ETs, particularly the pyrogenic and lethal activities of ETB not shared by ETA.
About this Structure
1QTF is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
The crystal structure of exfoliative toxin B: a superantigen with enzymatic activity., Vath GM, Earhart CA, Monie DD, Iandolo JJ, Schlievert PM, Ohlendorf DH, Biochemistry. 1999 Aug 10;38(32):10239-46. PMID:10441117 Page seeded by OCA on Sat May 3 06:41:10 2008
