1qxo

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[[Image:1qxo.jpg|left|200px]]
[[Image:1qxo.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1qxo |SIZE=350|CAPTION= <scene name='initialview01'>1qxo</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1qxo", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPS:5-[(1-CARBOXYVINYL)OXY]-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>EPS</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE+ION'>NCO</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Chorismate_synthase Chorismate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.5 4.2.3.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= AROC, SP1374 OR SPR1232 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])
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-->
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|DOMAIN=
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{{STRUCTURE_1qxo| PDB=1qxo | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qxo OCA], [http://www.ebi.ac.uk/pdbsum/1qxo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qxo RCSB]</span>
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}}
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'''Crystal structure of Chorismate synthase complexed with oxidized FMN and EPSP'''
'''Crystal structure of Chorismate synthase complexed with oxidized FMN and EPSP'''
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[[Category: Ali, S.]]
[[Category: Ali, S.]]
[[Category: Maclean, J.]]
[[Category: Maclean, J.]]
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[[Category: anti-infective]]
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[[Category: Anti-infective]]
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[[Category: beta-alpha-beta]]
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[[Category: Beta-alpha-beta]]
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[[Category: flavoprotein]]
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[[Category: Flavoprotein]]
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[[Category: shikimate]]
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[[Category: Shikimate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:49:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:20:27 2008''
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Revision as of 03:49, 3 May 2008

Image:1qxo.jpg

Template:STRUCTURE 1qxo

Crystal structure of Chorismate synthase complexed with oxidized FMN and EPSP


Overview

The crystal structure of chorismate synthase (CS) from Streptococcus pneumoniae has been solved to 2.0 A resolution in the presence of flavin mononucleotide (FMN) and the substrate 5-enolpyruvyl-3-shikimate phosphate (EPSP). CS catalyses the final step of the shikimate pathway and is a potential therapeutic target for the rational design of novel antibacterials, antifungals, antiprotozoals, and herbicides. CS is a tetramer with the monomer possessing a novel beta-alpha-beta fold. The interactions between the enzyme, cofactor, and substrate reveal the structural reasons underlying the unique catalytic mechanism and identify the amino acids involved. This structure provides the essential initial information necessary for the generation of novel anti-infective compounds by a structure-guided medicinal chemistry approach.

About this Structure

1QXO is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.

Reference

The structure of chorismate synthase reveals a novel flavin binding site fundamental to a unique chemical reaction., Maclean J, Ali S, Structure. 2003 Dec;11(12):1499-511. PMID:14656434 Page seeded by OCA on Sat May 3 06:49:38 2008

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