1qxw

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[[Image:1qxw.jpg|left|200px]]
[[Image:1qxw.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1qxw |SIZE=350|CAPTION= <scene name='initialview01'>1qxw</scene>, resolution 1.67&Aring;
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The line below this paragraph, containing "STRUCTURE_1qxw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=M1C:(3S)-3-AMINO-1-(CYCLOPROPYLAMINO)HEPTANE-2,2-DIOL'>M1C</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1qxw| PDB=1qxw | SCENE= }}
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|RELATEDENTRY=[[1qxy|1QXY]], [[1qxz|1QXZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qxw OCA], [http://www.ebi.ac.uk/pdbsum/1qxw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qxw RCSB]</span>
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}}
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'''Crystal structure of Staphyloccocus aureus in complex with an aminoketone inhibitor 54135.'''
'''Crystal structure of Staphyloccocus aureus in complex with an aminoketone inhibitor 54135.'''
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[[Category: Douangamath, A.]]
[[Category: Douangamath, A.]]
[[Category: Oefner, C.]]
[[Category: Oefner, C.]]
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[[Category: pita bread fold]]
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[[Category: Pita bread fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:50:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:20:34 2008''
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Revision as of 03:50, 3 May 2008

Image:1qxw.jpg

Template:STRUCTURE 1qxw

Crystal structure of Staphyloccocus aureus in complex with an aminoketone inhibitor 54135.


Overview

High-resolution crystal structures of Staphylococcus aureus methionine aminopeptidase I in complex with various keto heterocycles and aminoketones were determined, and the intermolecular ligand interactions with the enzyme are reported. The compounds are effective inhibitors of the S. aureus enzyme because of the formation of an uncleavable tetrahedral intermediate upon binding. The electron densities unequivocally show the enzyme-catalyzed transition-state analogue mimicking that for amide bond hydrolysis of substrates.

About this Structure

1QXW is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Crystal structures of Staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate., Douangamath A, Dale GE, D'Arcy A, Almstetter M, Eckl R, Frutos-Hoener A, Henkel B, Illgen K, Nerdinger S, Schulz H, Mac Sweeney A, Thormann M, Treml A, Pierau S, Wadman S, Oefner C, J Med Chem. 2004 Mar 11;47(6):1325-8. PMID:14998322 Page seeded by OCA on Sat May 3 06:50:01 2008

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