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4h5i

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Current revision (08:01, 3 November 2022) (edit) (undo)
 
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==Crystal Structure of the Guanine Nucleotide Exchange Factor Sec12 (P1 form)==
==Crystal Structure of the Guanine Nucleotide Exchange Factor Sec12 (P1 form)==
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<StructureSection load='4h5i' size='340' side='right' caption='[[4h5i]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
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<StructureSection load='4h5i' size='340' side='right'caption='[[4h5i]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4h5i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H5I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4h5i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H5I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h5i OCA], [https://pdbe.org/4h5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h5i RCSB], [https://www.ebi.ac.uk/pdbsum/4h5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h5i ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4h5j|4h5j]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SEC12, SED2, YNR026C, N3244 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h5i OCA], [http://pdbe.org/4h5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h5i RCSB], [http://www.ebi.ac.uk/pdbsum/4h5i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h5i ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SEC12_YEAST SEC12_YEAST]] Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER. This function involves the cytoplasmic domain of the protein, which is thought to interact with the small GTP-binding protein SAR1. Required for autophagy.<ref>PMID:11694599</ref> <ref>PMID:12655150</ref> <ref>PMID:1327759</ref> <ref>PMID:16413259</ref> <ref>PMID:1649197</ref> <ref>PMID:1907973</ref> <ref>PMID:1907974</ref> <ref>PMID:1922074</ref> <ref>PMID:2512296</ref> <ref>PMID:3047151</ref> <ref>PMID:6996832</ref> <ref>PMID:7865879</ref> <ref>PMID:8106544</ref> <ref>PMID:8377826</ref> <ref>PMID:8583945</ref> <ref>PMID:9023343</ref>
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[https://www.uniprot.org/uniprot/SEC12_YEAST SEC12_YEAST] Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER. This function involves the cytoplasmic domain of the protein, which is thought to interact with the small GTP-binding protein SAR1. Required for autophagy.<ref>PMID:11694599</ref> <ref>PMID:12655150</ref> <ref>PMID:1327759</ref> <ref>PMID:16413259</ref> <ref>PMID:1649197</ref> <ref>PMID:1907973</ref> <ref>PMID:1907974</ref> <ref>PMID:1922074</ref> <ref>PMID:2512296</ref> <ref>PMID:3047151</ref> <ref>PMID:6996832</ref> <ref>PMID:7865879</ref> <ref>PMID:8106544</ref> <ref>PMID:8377826</ref> <ref>PMID:8583945</ref> <ref>PMID:9023343</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 18824]]
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[[Category: Large Structures]]
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[[Category: Hughson, F M]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Jeffrey, P D]]
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[[Category: Hughson FM]]
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[[Category: McMahon, C]]
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[[Category: Jeffrey PD]]
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[[Category: Beta propeller]]
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[[Category: McMahon C]]
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[[Category: Copii vesicle budding]]
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[[Category: Potassium binding site]]
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[[Category: Protein transport]]
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Current revision

Crystal Structure of the Guanine Nucleotide Exchange Factor Sec12 (P1 form)

PDB ID 4h5i

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