1qyy

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[[Image:1qyy.jpg|left|200px]]
[[Image:1qyy.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1qyy |SIZE=350|CAPTION= <scene name='initialview01'>1qyy</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1qyy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= GP1BA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1qyy| PDB=1qyy | SCENE= }}
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|RELATEDENTRY=[[1p9a|1P9A]], [[100k|100K]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qyy OCA], [http://www.ebi.ac.uk/pdbsum/1qyy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qyy RCSB]</span>
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}}
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'''Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 2.8 Angstrom Resolution'''
'''Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 2.8 Angstrom Resolution'''
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[[Category: Ruggeri, Z M.]]
[[Category: Ruggeri, Z M.]]
[[Category: Varughese, K I.]]
[[Category: Varughese, K I.]]
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[[Category: glycocalicin]]
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[[Category: Glycocalicin]]
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[[Category: leucine rich repeat]]
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[[Category: Leucine rich repeat]]
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[[Category: platelet receptor]]
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[[Category: Platelet receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:52:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:20:56 2008''
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Revision as of 03:52, 3 May 2008

Image:1qyy.jpg

Template:STRUCTURE 1qyy

Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-alpha at 2.8 Angstrom Resolution


Contents

Overview

The interaction between platelet glycoprotein (GP) Ib alpha and von Willebrand factor (VWF) is essential for thrombus formation, leading to the arrest of bleeding. The N-terminal domain of GP Ib alpha, which contains the binding sites for VWF and alpha-thrombin, crystallized in the tetragonal space group P4(3) with one molecule in the asymmetric unit. When the crystals were treated with platinum, the crystals changed their symmetry from tetragonal to monoclinic P2(1) with two molecules in the asymmetric unit. The structure of the monoclinic form was solved using two-wavelength platinum anomalous dispersion data. The tetragonal crystal structure was subsequently solved using molecular-replacement techniques using the monoclinic structure as the search model and was refined with 1.7 A resolution data.

Disease

Known disease associated with this structure: Bernard-Soulier syndrome, type A OMIM:[606672], von Willebrand disease, platelet-type OMIM:[606672], Nonarteritic anterior ischemic optic neuropathy, susceptibility to OMIM:[606672]

About this Structure

1QYY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Platinum-induced space-group transformation in crystals of the platelet glycoprotein Ib alpha N-terminal domain., Varughese KI, Ruggeri ZM, Celikel R, Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):405-11. Epub 2004, Feb 25. PMID:14993663 Page seeded by OCA on Sat May 3 06:52:22 2008

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OCA

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