1qza

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[[Image:1qza.gif|left|200px]]
[[Image:1qza.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1qza |SIZE=350|CAPTION= <scene name='initialview01'>1qza</scene>
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The line below this paragraph, containing "STRUCTURE_1qza", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1qza| PDB=1qza | SCENE= }}
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|RELATEDENTRY=[[1ob2|1OB2]], [[1qzb|1QZB]], [[1qzc|1QZC]], [[1qzd|1QZD]], [[1r2w|1R2W]], [[1r2x|1R2X]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qza OCA], [http://www.ebi.ac.uk/pdbsum/1qza PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qza RCSB]</span>
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}}
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'''Coordinates of the A/T site tRNA model fitted into the cryo-EM map of EF-Tu ternary complex (GDP.Kirromycin) bound 70S ribosome'''
'''Coordinates of the A/T site tRNA model fitted into the cryo-EM map of EF-Tu ternary complex (GDP.Kirromycin) bound 70S ribosome'''
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==About this Structure==
==About this Structure==
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1QZA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZA OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZA OCA].
==Reference==
==Reference==
Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy., Valle M, Zavialov A, Li W, Stagg SM, Sengupta J, Nielsen RC, Nissen P, Harvey SC, Ehrenberg M, Frank J, Nat Struct Biol. 2003 Nov;10(11):899-906. Epub 2003 Oct 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14566331 14566331]
Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy., Valle M, Zavialov A, Li W, Stagg SM, Sengupta J, Nielsen RC, Nissen P, Harvey SC, Ehrenberg M, Frank J, Nat Struct Biol. 2003 Nov;10(11):899-906. Epub 2003 Oct 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14566331 14566331]
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[[Category: Protein complex]]
 
[[Category: Ehrenberg, M.]]
[[Category: Ehrenberg, M.]]
[[Category: Frank, J.]]
[[Category: Frank, J.]]
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[[Category: Valle, M.]]
[[Category: Valle, M.]]
[[Category: Zavialov, A.]]
[[Category: Zavialov, A.]]
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[[Category: a/t-site trna.]]
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[[Category: A/t-site trna.]]
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[[Category: decoding]]
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[[Category: Decoding]]
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[[Category: trna model]]
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[[Category: Trna model]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:53:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:21:04 2008''
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Revision as of 03:53, 3 May 2008

Image:1qza.gif

Template:STRUCTURE 1qza

Coordinates of the A/T site tRNA model fitted into the cryo-EM map of EF-Tu ternary complex (GDP.Kirromycin) bound 70S ribosome


Overview

Aminoacyl-tRNAs (aa-tRNAs) are delivered to the ribosome as part of the ternary complex of aa-tRNA, elongation factor Tu (EF-Tu) and GTP. Here, we present a cryo-electron microscopy (cryo-EM) study, at a resolution of approximately 9 A, showing that during the incorporation of the aa-tRNA into the 70S ribosome of Escherichia coli, the flexibility of aa-tRNA allows the initial codon recognition and its accommodation into the ribosomal A site. In addition, a conformational change observed in the GTPase-associated center (GAC) of the ribosomal 50S subunit may provide the mechanism by which the ribosome promotes a relative movement of the aa-tRNA with respect to EF-Tu. This relative rearrangement seems to facilitate codon recognition by the incoming aa-tRNA, and to provide the codon-anticodon recognition-dependent signal for the GTPase activity of EF-Tu. From these new findings we propose a mechanism that can explain the sequence of events during the decoding of mRNA on the ribosome.

About this Structure

Full crystallographic information is available from OCA.

Reference

Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy., Valle M, Zavialov A, Li W, Stagg SM, Sengupta J, Nielsen RC, Nissen P, Harvey SC, Ehrenberg M, Frank J, Nat Struct Biol. 2003 Nov;10(11):899-906. Epub 2003 Oct 19. PMID:14566331 Page seeded by OCA on Sat May 3 06:53:18 2008

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