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1qz6

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[[Image:1qz6.jpg|left|200px]]
[[Image:1qz6.jpg|left|200px]]
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{{Structure
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|PDB= 1qz6 |SIZE=350|CAPTION= <scene name='initialview01'>1qz6</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1qz6", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=JAS:JASPISAMIDE+A'>JAS</scene>, <scene name='pdbligand=SUC:SUCROSE'>SUC</scene>
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{{STRUCTURE_1qz6| PDB=1qz6 | SCENE= }}
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|RELATEDENTRY=[[1qz5|1QZ5]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz6 OCA], [http://www.ebi.ac.uk/pdbsum/1qz6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qz6 RCSB]</span>
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'''Structure of rabbit actin in complex with jaspisamide A'''
'''Structure of rabbit actin in complex with jaspisamide A'''
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[[Category: Rayment, I.]]
[[Category: Rayment, I.]]
[[Category: Tanaka, J.]]
[[Category: Tanaka, J.]]
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[[Category: actin]]
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[[Category: Actin]]
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[[Category: jaspisamide some]]
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[[Category: Jaspisamide some]]
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[[Category: toxin]]
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[[Category: Toxin]]
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[[Category: trisoxazole]]
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[[Category: Trisoxazole]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:52:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:21:04 2008''
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Revision as of 03:52, 3 May 2008

Image:1qz6.jpg

Template:STRUCTURE 1qz6

Structure of rabbit actin in complex with jaspisamide A


Overview

Marine macrolide toxins of trisoxazole family target actin with high affinity and specificity and have promising pharmacological properties. We present X-ray structures of actin in complex with two members of this family, kabiramide C and jaspisamide A, at a resolution of 1.45 and 1.6 A, respectively. The structures reveal the absolute stereochemistry of these toxins and demonstrate that their trisoxazole ring interacts with actin subdomain 1 while the aliphatic side chain is inserted into the hydrophobic cavity between actin subdomains 1 and 3. The binding site is essentially the same as the one occupied by the actin-capping domain of the gelsolin superfamily of proteins. The structural evidence suggests that actin filament severing and capping by these toxins is also analogous to that of gelsolin. Consequently, these macrolides may be viewed as small molecule biomimetics of an entire class of actin-binding proteins.

About this Structure

1QZ6 is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin., Klenchin VA, Allingham JS, King R, Tanaka J, Marriott G, Rayment I, Nat Struct Biol. 2003 Dec;10(12):1058-63. Epub 2003 Oct 26. PMID:14578936 Page seeded by OCA on Sat May 3 06:52:57 2008

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