4tsz
From Proteopedia
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==Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa with ligand== | ==Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa with ligand== | ||
| - | <StructureSection load='4tsz' size='340' side='right' caption='[[4tsz]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='4tsz' size='340' side='right'caption='[[4tsz]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4tsz]] is a 32 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TSZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4tsz]] is a 32 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TSZ FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ALC:2-AMINO-3-CYCLOHEXYL-PROPIONIC+ACID'>ALC</scene>, <scene name='pdbligand=ZCL:3,4-DICHLORO-L-PHENYLALANINE'>ZCL</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ALC:2-AMINO-3-CYCLOHEXYL-PROPIONIC+ACID'>ALC</scene>, <scene name='pdbligand=ZCL:3,4-DICHLORO-L-PHENYLALANINE'>ZCL</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tsz OCA], [http://pdbe.org/4tsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tsz RCSB], [http://www.ebi.ac.uk/pdbsum/4tsz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tsz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tsz OCA], [http://pdbe.org/4tsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tsz RCSB], [http://www.ebi.ac.uk/pdbsum/4tsz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tsz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | {{Large structure}} | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/V4MZL6_PSEAI V4MZL6_PSEAI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).[PIRNR:PIRNR000804] | [[http://www.uniprot.org/uniprot/V4MZL6_PSEAI V4MZL6_PSEAI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).[PIRNR:PIRNR000804] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: DNA-directed DNA polymerase]] | [[Category: DNA-directed DNA polymerase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Burnouf, D]] | [[Category: Burnouf, D]] | ||
[[Category: Ennifar, E]] | [[Category: Ennifar, E]] | ||
Revision as of 15:05, 10 May 2019
Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa with ligand
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