1qzy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1qzy.jpg|left|200px]]
[[Image:1qzy.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1qzy |SIZE=350|CAPTION= <scene name='initialview01'>1qzy</scene>, resolution 1.60&Aring;
+
The line below this paragraph, containing "STRUCTURE_1qzy", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene>, <scene name='pdbligand=TDE:(E)-(2R,3R,4S,5R)-3,4,5-TRIHYDROXY-2-METHOXY-8,8-DIMETHYL-NON-6-ENOIC+ACID+((3S,6R)-6-HYDROXY-2-OXO-AZEPAN-3-YL)-AMIDE'>TDE</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1qzy| PDB=1qzy | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qzy OCA], [http://www.ebi.ac.uk/pdbsum/1qzy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qzy RCSB]</span>
+
-
}}
+
'''Human Methionine Aminopeptidase in complex with bengamide inhibitor LAF153 and cobalt'''
'''Human Methionine Aminopeptidase in complex with bengamide inhibitor LAF153 and cobalt'''
Line 29: Line 26:
[[Category: Morollo, A.]]
[[Category: Morollo, A.]]
[[Category: Song, H K.]]
[[Category: Song, H K.]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:54:27 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:21:28 2008''
+

Revision as of 03:54, 3 May 2008

Image:1qzy.jpg

Template:STRUCTURE 1qzy

Human Methionine Aminopeptidase in complex with bengamide inhibitor LAF153 and cobalt


Overview

LAF389 is a synthetic analogue of bengamides, a class of marine natural products that produce inhibitory effects on tumor growth in vitro and in vivo. A proteomics-based approach has been used to identify signaling pathways affected by bengamides. LAF389 treatment of cells resulted in altered mobility of a subset of proteins on two-dimensional gel electrophoresis. Detailed analysis of one of the proteins, 14-3-3gamma, showed that bengamide treatment resulted in retention of the amino-terminal methionine, suggesting that bengamides directly or indirectly inhibited methionine aminopeptidases (MetAps). Both known MetAps are inhibited by LAF389. Short interfering RNA suppression of MetAp2 also altered amino-terminal processing of 14-3-3gamma. A high resolution structure of human MetAp2 co-crystallized with a bengamide shows that the compound binds in a manner that mimics peptide substrates. Additionally, the structure reveals that three key hydroxyl groups on the inhibitor coordinate the di-cobalt center in the enzyme active site.

About this Structure

1QZY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors., Towbin H, Bair KW, DeCaprio JA, Eck MJ, Kim S, Kinder FR, Morollo A, Mueller DR, Schindler P, Song HK, van Oostrum J, Versace RW, Voshol H, Wood J, Zabludoff S, Phillips PE, J Biol Chem. 2003 Dec 26;278(52):52964-71. Epub 2003 Oct 8. PMID:14534293 Page seeded by OCA on Sat May 3 06:54:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qzy"
Personal tools