5wsq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of C-Hg-T pair containing DNA duplex== | |
| + | <StructureSection load='5wsq' size='340' side='right' caption='[[5wsq]], [[Resolution|resolution]] 1.05Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5wsq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WSQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WSQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=PDO:1,3-PROPANDIOL'>PDO</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wsp|5wsp]], [[5wsr|5wsr]], [[5wss|5wss]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wsq OCA], [http://pdbe.org/5wsq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wsq RCSB], [http://www.ebi.ac.uk/pdbsum/5wsq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wsq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Owing to their great potentials in genetic code extension and the development of nucleic acid-based functional nanodevices, DNA duplexes containing HgII-mediated base pairs have been extensively studied during the past 60 years. However, structural basis underlying these base pairs remains poorly understood. Herein, we present five high-resolution crystal structures including one first-time reported C-HgII-T containing duplex, three T-HgII-T containing duplexes and one native duplex containing T-T pair without HgII Our structures suggest that both C-T and T-T pairs are flexible in interacting with the HgII ion with various binding modes including N3-HgII-N3, N4-HgII-N3, O2-HgII-N3 and N3-HgII-O4. Our studies also reveal that the overall conformations of the C-HgII-T and T-HgII-T pairs are affected by their neighboring residues via the interactions with the solvent molecules or other metal ions, such as SrII These results provide detailed insights into the interactions between HgII and nucleobases and the structural basis for the rational design of C-HgII-T or T-HgII-T containing DNA nanodevices in the future. | ||
| - | + | Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex.,Liu H, Cai C, Haruehanroengra P, Yao Q, Chen Y, Yang C, Luo Q, Wu B, Li J, Ma J, Sheng J, Gan J Nucleic Acids Res. 2016 Dec 19. pii: gkw1296. doi: 10.1093/nar/gkw1296. PMID:27998930<ref>PMID:27998930</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5wsq" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gan, J H]] | ||
| + | [[Category: Liu, H H]] | ||
| + | [[Category: C-hg-t pair]] | ||
| + | [[Category: Dna]] | ||
| + | [[Category: Dna duplex]] | ||
Revision as of 09:31, 10 March 2017
Crystal structure of C-Hg-T pair containing DNA duplex
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Categories: Gan, J H | Liu, H H | C-hg-t pair | Dna | Dna duplex
