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1r2q

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[[Image:1r2q.gif|left|200px]]
[[Image:1r2q.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1r2q |SIZE=350|CAPTION= <scene name='initialview01'>1r2q</scene>, resolution 1.05&Aring;
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The line below this paragraph, containing "STRUCTURE_1r2q", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= RAB5A OR RAB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1r2q| PDB=1r2q | SCENE= }}
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|RELATEDENTRY=[[1n6h|1N6H]], [[1n6i|1N6I]], [[1n6k|1N6K]], [[1n6l|1N6L]], [[1n6n|1N6N]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2q OCA], [http://www.ebi.ac.uk/pdbsum/1r2q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r2q RCSB]</span>
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}}
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'''Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution'''
'''Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution'''
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[[Category: Zhang, X C.]]
[[Category: Zhang, X C.]]
[[Category: Zhu, G.]]
[[Category: Zhu, G.]]
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[[Category: atomic resolution]]
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[[Category: Atomic resolution]]
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[[Category: gnp]]
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[[Category: Gnp]]
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[[Category: gtpase]]
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[[Category: Gtpase]]
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[[Category: rab]]
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[[Category: Rab]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:00:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:22:27 2008''
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Revision as of 04:00, 3 May 2008

Image:1r2q.gif

Template:STRUCTURE 1r2q

Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution


Overview

Rab5 is a GTPase that regulates early endosome fusion. Its GTPase domain crystal structure is reported here at 1.05 A resolution in complex with a GTP-analog molecule. It provides the highest resolution three-dimensional model so far obtained for proteins from the Ras-like GTPase family. This study allows extension of structural examination of the GTPase machinery as well as of high-resolution protein structures in general. For example, a buried water-molecule network was observed underneath the switch regions, which is consistent with the functional roles of these regions in the molecular-switching process. Furthermore, residues of multiple conformation and clustered distribution of anisotropic thermal motions of the protein molecule may have general implications for the function of Ras-like GTPases.

About this Structure

1R2Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution., Terzyan S, Zhu G, Li G, Zhang XC, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):54-60. Epub 2003, Dec 18. PMID:14684892 Page seeded by OCA on Sat May 3 07:00:13 2008

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