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1r44

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[[Image:1r44.jpg|left|200px]]
[[Image:1r44.jpg|left|200px]]
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{{Structure
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|PDB= 1r44 |SIZE=350|CAPTION= <scene name='initialview01'>1r44</scene>, resolution 2.25&Aring;
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The line below this paragraph, containing "STRUCTURE_1r44", creates the "Structure Box" on the page.
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|GENE= VANX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 Enterococcus faecium])
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{{STRUCTURE_1r44| PDB=1r44 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r44 OCA], [http://www.ebi.ac.uk/pdbsum/1r44 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r44 RCSB]</span>
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'''Crystal Structure of VanX'''
'''Crystal Structure of VanX'''
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[[Category: Pratt, S D.]]
[[Category: Pratt, S D.]]
[[Category: Severin, J M.]]
[[Category: Severin, J M.]]
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[[Category: dipeptidase]]
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[[Category: Dipeptidase]]
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[[Category: e faecium]]
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[[Category: E faecium]]
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[[Category: vanx]]
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[[Category: Vanx]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:02:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:22:59 2008''
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Revision as of 04:02, 3 May 2008

Image:1r44.jpg

Template:STRUCTURE 1r44

Crystal Structure of VanX


Overview

VanX is a zinc-dependent D-alanyl-D-alanine dipeptidase that is a critical component in a system that mediates transposon-based vancomycin resistance in enterococci. It is also a key drug target in circumventing clinical vancomycin resistance. The structure of VanX from E. faecium has been solved by X-ray crystallography and reveals a Zn(2+)-dipeptidase with a unique overall fold and a well-defined active site confined within a cavity of limited size. The crystal structures of VanX, the VanX:D-alanyl-D-alanine complex, the VanX:D-alanine complex, and VanX in complex with phosphonate and phosphinate transition-state analog inhibitors, are also presented at high resolution. Structural homology searches of known structures revealed that the fold of VanX is similar to those of two proteins: the N-terminal fragment of murine Sonic hedgehog and the Zn(2+)-dependent N-acyl-D-alanyl-D-alanine carboxypeptidase of S. albus G.

About this Structure

1R44 is a Single protein structure of sequence from Enterococcus faecium. Full crystallographic information is available from OCA.

Reference

The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance., Bussiere DE, Pratt SD, Katz L, Severin JM, Holzman T, Park CH, Mol Cell. 1998 Jul;2(1):75-84. PMID:9702193 Page seeded by OCA on Sat May 3 07:02:55 2008

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