1r5u

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[[Image:1r5u.gif|left|200px]]
[[Image:1r5u.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1r5u |SIZE=350|CAPTION= <scene name='initialview01'>1r5u</scene>, resolution 4.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1r5u", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Sua7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_1r5u| PDB=1r5u | SCENE= }}
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|RELATEDENTRY=[[1i6h|1I6h]], [[1pft|1pft]], [[1dl6|1dl6]], [[1i3q|1I3q]], [[1i5o|1I5o]], [[1nik|1NIK]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5u OCA], [http://www.ebi.ac.uk/pdbsum/1r5u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r5u RCSB]</span>
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}}
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'''RNA POLYMERASE II TFIIB COMPLEX'''
'''RNA POLYMERASE II TFIIB COMPLEX'''
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[[Category: Kornberg, R D.]]
[[Category: Kornberg, R D.]]
[[Category: Westover, K D.]]
[[Category: Westover, K D.]]
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[[Category: zinc ribbon]]
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[[Category: Zinc ribbon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:07:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:23:40 2008''
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Revision as of 04:07, 3 May 2008

Image:1r5u.gif

Template:STRUCTURE 1r5u

RNA POLYMERASE II TFIIB COMPLEX


Overview

The structure of the general transcription factor IIB (TFIIB) in a complex with RNA polymerase II reveals three features crucial for transcription initiation: an N-terminal zinc ribbon domain of TFIIB that contacts the "dock" domain of the polymerase, near the path of RNA exit from a transcribing enzyme; a "finger" domain of TFIIB that is inserted into the polymerase active center; and a C-terminal domain, whose interaction with both the polymerase and with a TATA box-binding protein (TBP)-promoter DNA complex orients the DNA for unwinding and transcription. TFIIB stabilizes an early initiation complex, containing an incomplete RNA-DNA hybrid region. It may interact with the template strand, which sets the location of the transcription start site, and may interfere with RNA exit, which leads to abortive initiation or promoter escape. The trajectory of promoter DNA determined by the C-terminal domain of TFIIB traverses sites of interaction with TFIIE, TFIIF, and TFIIH, serving to define their roles in the transcription initiation process.

About this Structure

1R5U is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms., Bushnell DA, Westover KD, Davis RE, Kornberg RD, Science. 2004 Feb 13;303(5660):983-8. PMID:14963322 Page seeded by OCA on Sat May 3 07:07:02 2008

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OCA

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