Aldo-keto reductase
From Proteopedia
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== Function == | == Function == | ||
Aldo-keto reductase (AKR) is a protein family which contains enzymes that reduce carbonyl substrates like sugar aldehyde, keto-steroid, keto-prostaglandin, retinal, quinones and lipid peroxidation by-products to primary alcohol<ref>PMID:25304492</ref>. AKR uses NADP as a cofactor. AKRs contain a conserved catalytic tetrad consisting of Tyr, Asp, Lys and His. | Aldo-keto reductase (AKR) is a protein family which contains enzymes that reduce carbonyl substrates like sugar aldehyde, keto-steroid, keto-prostaglandin, retinal, quinones and lipid peroxidation by-products to primary alcohol<ref>PMID:25304492</ref>. AKR uses NADP as a cofactor. AKRs contain a conserved catalytic tetrad consisting of Tyr, Asp, Lys and His. | ||
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**[[2wzt]] – MsAKR – ''Mycobacterium smegmatis''<br /> | **[[2wzt]] – MsAKR – ''Mycobacterium smegmatis''<br /> | ||
**[[2wzm]] – MsAKR + ligand<br /> | **[[2wzm]] – MsAKR + ligand<br /> | ||
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==References== | ==References== | ||
Revision as of 11:16, 28 December 2016
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