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5mgt

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'''Unreleased structure'''
 
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The entry 5mgt is ON HOLD until Paper Publication
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==Complex of human NKR-P1 and LLT1 in deglycosylated forms==
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<StructureSection load='5mgt' size='340' side='right' caption='[[5mgt]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5mgt]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MGT FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mgt OCA], [http://pdbe.org/5mgt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mgt RCSB], [http://www.ebi.ac.uk/pdbsum/5mgt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mgt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CLC2D_HUMAN CLC2D_HUMAN]] Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.<ref>PMID:14753741</ref> <ref>PMID:15104121</ref> <ref>PMID:16339513</ref> [[http://www.uniprot.org/uniprot/KLRB1_HUMAN KLRB1_HUMAN]] Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.<ref>PMID:16455998</ref> <ref>PMID:16925668</ref> <ref>PMID:8077657</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Blaha, J]]
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[[Category: Dohnalek, J]]
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[[Category: Harlos, K]]
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[[Category: Hasek, J]]
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[[Category: Koval, T]]
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[[Category: Skalova, T]]
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[[Category: Stransky, J]]
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[[Category: Vanek, O]]
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[[Category: Yuguang, Z]]
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[[Category: Ctl fold]]
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[[Category: Immune system]]
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[[Category: Natural killer cell]]
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[[Category: Receptor]]
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[[Category: Receptor-ligand complex]]

Revision as of 05:47, 6 June 2018

Complex of human NKR-P1 and LLT1 in deglycosylated forms

5mgt, resolution 1.90Å

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