1r74

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[[Image:1r74.jpg|left|200px]]
[[Image:1r74.jpg|left|200px]]
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{{Structure
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|PDB= 1r74 |SIZE=350|CAPTION= <scene name='initialview01'>1r74</scene>, resolution 2.55&Aring;
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The line below this paragraph, containing "STRUCTURE_1r74", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_N-methyltransferase Glycine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.20 2.1.1.20] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= GNMT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1r74| PDB=1r74 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r74 OCA], [http://www.ebi.ac.uk/pdbsum/1r74 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r74 RCSB]</span>
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}}
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'''Crystal Structure of Human Glycine N-Methyltransferase'''
'''Crystal Structure of Human Glycine N-Methyltransferase'''
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[[Category: Pakhomova, S.]]
[[Category: Pakhomova, S.]]
[[Category: Wagner, C.]]
[[Category: Wagner, C.]]
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[[Category: glycine n-methyltransferase]]
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[[Category: Glycine n-methyltransferase]]
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[[Category: human]]
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[[Category: Human]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:09:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:24:14 2008''
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Revision as of 04:09, 3 May 2008

Image:1r74.jpg

Template:STRUCTURE 1r74

Crystal Structure of Human Glycine N-Methyltransferase


Contents

Overview

Glycine N-methyltransferases (GNMTs) from three mammalian sources were compared with respect to their crystal structures and kinetic parameters. The crystal structure for the rat enzyme was published previously. Human and mouse GNMT were expressed in Escherichia coli in order to determine their crystal structures. Mouse GNMT was crystallized in two crystal forms, a monoclinic form and a tetragonal form. Comparison of the three structures reveals subtle differences, which may relate to the different kinetic properties of the enzymes.The flexible character of several loops surrounding the active site, along with an analysis of the active site boundaries, indicates that the observed conformations of human and mouse GNMTs are more open than that of the rat enzyme. There is an increase in kcat when going from rat to mouse to human, suggesting a correlation with the increased flexibility of some structural elements of the respective enzymes.

Disease

Known disease associated with this structure: Glycine N-methyltransferase deficiency OMIM:[606628]

About this Structure

1R74 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes., Pakhomova S, Luka Z, Grohmann S, Wagner C, Newcomer ME, Proteins. 2004 Nov 1;57(2):331-7. PMID:15340920 Page seeded by OCA on Sat May 3 07:09:54 2008

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