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1r7r

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[[Image:1r7r.gif|left|200px]]
[[Image:1r7r.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1r7r |SIZE=350|CAPTION= <scene name='initialview01'>1r7r</scene>, resolution 3.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1r7r", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= VCP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_1r7r| PDB=1r7r | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7r OCA], [http://www.ebi.ac.uk/pdbsum/1r7r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r7r RCSB]</span>
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'''The crystal structure of murine p97/VCP at 3.6A'''
'''The crystal structure of murine p97/VCP at 3.6A'''
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[[Category: Pye, V E.]]
[[Category: Pye, V E.]]
[[Category: Zhang, X.]]
[[Category: Zhang, X.]]
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[[Category: aaa]]
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[[Category: Aaa]]
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[[Category: cdc48]]
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[[Category: Cdc48]]
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[[Category: p97]]
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[[Category: P97]]
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[[Category: vcp]]
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[[Category: Vcp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:11:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:24:27 2008''
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Revision as of 04:11, 3 May 2008

Image:1r7r.gif

Template:STRUCTURE 1r7r

The crystal structure of murine p97/VCP at 3.6A


Overview

p97/VCP is a member of the AAA ATPase family and has roles in both membrane fusion and ubiquitin dependent protein degradation. Here, we present a 3.6A crystal structure of murine p97 in which D2 domain has been modelled as poly-alanine and the remaining approximately 100 residues are absent. The resulting structure illustrates a head-to-tail packing arrangement of the two p97 AAA domains in a natural hexameric state with D1 ADP bound and D2 nucleotide free. The head-to-tail packing arrangement observed in this structure is in contrast to our previously predicted tail-to-tail packing model. The linker between the D1 and D2 domains is partially disordered, suggesting a flexible nature. Normal mode analysis of the crystal structure suggests anti-correlated motions and distinct conformational states of the two AAA domains.

About this Structure

1R7R is a Single protein structure of sequence from Mus musculus. The following page contains interesting information on the relation of 1R7R with [AAA+ Proteases]. Full crystallographic information is available from OCA.

Reference

The crystal structure of murine p97/VCP at 3.6A., Huyton T, Pye VE, Briggs LC, Flynn TC, Beuron F, Kondo H, Ma J, Zhang X, Freemont PS, J Struct Biol. 2003 Dec;144(3):337-48. PMID:14643202 Page seeded by OCA on Sat May 3 07:11:13 2008

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