4opn
From Proteopedia
(Difference between revisions)
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==Crystal structure of mouse glyoxalase I complexed with mAH== | ==Crystal structure of mouse glyoxalase I complexed with mAH== | ||
| - | <StructureSection load='4opn' size='340' side='right' caption='[[4opn]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='4opn' size='340' side='right'caption='[[4opn]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4opn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OPN FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4opn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OPN FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZBF:L-GAMMA-GLUTAMYL-N-(3-ETHYNYLPHENYL)-N-HYDROXY-L-GLUTAMINYLGLYCINE'>ZBF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZBF:L-GAMMA-GLUTAMYL-N-(3-ETHYNYLPHENYL)-N-HYDROXY-L-GLUTAMINYLGLYCINE'>ZBF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Glo1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactoylglutathione_lyase Lactoylglutathione lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.5 4.4.1.5] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactoylglutathione_lyase Lactoylglutathione lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.5 4.4.1.5] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4opn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4opn OCA], [http://pdbe.org/4opn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4opn RCSB], [http://www.ebi.ac.uk/pdbsum/4opn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4opn ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4opn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4opn OCA], [http://pdbe.org/4opn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4opn RCSB], [http://www.ebi.ac.uk/pdbsum/4opn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4opn ProSAT]</span></td></tr> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/LGUL_MOUSE LGUL_MOUSE]] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). | [[http://www.uniprot.org/uniprot/LGUL_MOUSE LGUL_MOUSE]] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). | ||
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| + | ==See Also== | ||
| + | *[[Glyoxalase|Glyoxalase]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Lactoylglutathione lyase]] | [[Category: Lactoylglutathione lyase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lk3 transgenic mice]] | ||
[[Category: Yuan, M]] | [[Category: Yuan, M]] | ||
[[Category: Zhai, J]] | [[Category: Zhai, J]] | ||
Revision as of 08:05, 17 April 2019
Crystal structure of mouse glyoxalase I complexed with mAH
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