Virion infectivity factor

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Revision as of 17:50, 16 October 2017

spinqualitylabelsall models HIV-1 virion infectivity factor (grey) complex with human elongin-B Green) and elongin-C (pink) (PDB code 2ma9) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Virion infectivity factor (Vif) of HIV-1 is essential for efficient viral replication by binding to the a component of the innate immune system and triggering its polyubiquitination and rapid degradation thus preventing its entry into progeny virions[1]. For details see HIV and accessory proteins

3D Structures of virion infectivity factor

Updated on 16-October-2017

4n9f – Vif + cullin-5 + elongin-C + elongin-B + CBF-β – HIV-1
2ma9, 3dcg – Vif + elongin-C + elongin-B – HIV-1

References

1. ↑ Rose KM, Marin M, Kozak SL, Kabat D. The viral infectivity factor (Vif) of HIV-1 unveiled. Trends Mol Med. 2004 Jun;10(6):291-7. PMID:15177194 doi:http://dx.doi.org/10.1016/j.molmed.2004.04.008