User:Camille Zumstein/Sandbox

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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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'''General structure of calcineurin''':
 
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Calcineurin is a heterodimeric Protein that consits of two subunits.
 
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This structure presented in this article is the catalytic subunit isoform of the serine/threonine-protein phosphatase 2B, also known as calcineurin in rattus norvegicus (rat).
 
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''' Localisation and expression''':
''' Localisation and expression''':
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== General structure ==
== General structure ==
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The phosphatase <scene name='75/750223/Jw_caln_sec_strcutur/1'>Calcineurin</scene> consists of 521 <ref>http://www.uniprot.org/uniprot/P63329</ref> aminoacids. The structure have been published 2013 by Qilu Ye et al. <ref>http://www.sciencedirect.com/science/article/pii/S0898656813002702</ref>. For their experiments they used [https://en.wikipedia.org/wiki/X-ray_crystallography#X-ray_diffraction x-ray diffraction]. The PDB validation obtained a Resolutionof 3.0 Å, a free R-value of 0.273 and a work R-value of 0.241 <ref>http://www.rcsb.org/pdb/explore/explore.do?structureId=4IL1</ref>.
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<scene name='75/750223/Jw_caln_sec_strcutur/1'>Calcineurin</scene> is a heterodimeric Protein that consits of two subunits. They are called catalytic and regulatory subunit.
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This structure presented in this article is the catalytic subunit isoform of the serine/threonine-protein phosphatase 2B in rattus norvegicus (rat). It consists of 521 <ref>http://www.uniprot.org/uniprot/P63329</ref> aminoacids and has a molecular weight of 57 kDa.
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'''Discovery of the strucutre:'''
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The structure have been published in the year 2013 by Qilu Ye et al. <ref>http://www.sciencedirect.com/science/article/pii/S0898656813002702</ref>. For their experiments they used [https://en.wikipedia.org/wiki/X-ray_crystallography#X-ray_diffraction x-ray diffraction]. The PDB validation obtained a Resolutionof 3.0 Å, a free R-value of 0.273 and a work R-value of 0.241 <ref>http://www.rcsb.org/pdb/explore/explore.do?structureId=4IL1</ref>.
[[Image:4il1 multipercentile validation.png|thumb|left|400 px]]
[[Image:4il1 multipercentile validation.png|thumb|left|400 px]]
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Revision as of 11:02, 8 January 2017

Structure Rat Calcineurin

Rat calcineurin monomer

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ http://www.jimmunol.org/content/177/4/2681.full
  4. ↑ http://www.uniprot.org/uniprot/P63329
  5. ↑ http://www.sciencedirect.com/science/article/pii/S0898656813002702
  6. ↑ http://www.rcsb.org/pdb/explore/explore.do?structureId=4IL1
  7. ↑ https://www.ncbi.nlm.nih.gov/pubmed/8811062
  8. ↑ http://www.uptodate.com/contents/pharmacology-of-cyclosporine-and-tacrolimus

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Camille Zumstein

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