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1rgs

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[[Image:1rgs.gif|left|200px]]
[[Image:1rgs.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1rgs |SIZE=350|CAPTION= <scene name='initialview01'>1rgs</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1rgs", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CMP:ADENOSINE-3&#39;,5&#39;-CYCLIC-MONOPHOSPHATE'>CMP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= BOVINE SKELETON MUSCLE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])
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-->
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|DOMAIN=
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{{STRUCTURE_1rgs| PDB=1rgs | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rgs OCA], [http://www.ebi.ac.uk/pdbsum/1rgs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rgs RCSB]</span>
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}}
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'''REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE'''
'''REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE'''
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[[Category: Varughese, K I.]]
[[Category: Varughese, K I.]]
[[Category: Xuong, N H.]]
[[Category: Xuong, N H.]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: regulatory subunit]]
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[[Category: Regulatory subunit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:28:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:27:55 2008''
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Revision as of 04:28, 3 May 2008

Image:1rgs.gif

Template:STRUCTURE 1rgs

REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE


Overview

In the molecular scheme of living organisms, adenosine 3',5'-monophosphate (cyclic AMP or cAMP) has been a universal second messenger. In eukaryotic cells, the primary receptors for cAMP are the regulatory subunits of cAMP-dependent protein kinase. The crystal structure of a 1-91 deletion mutant of the type I alpha regulatory subunit was refined to 2.8 A resolution. Each of the two tandem cAMP binding domains provides an extensive network of hydrogen bonds that buries the cyclic phosphate and the ribose between two beta strands that are linked by a short alpha helix. Each adenine base stacks against an aromatic ring that lies outside the beta barrel. This structure provides a molecular basis for understanding how cAMP binds cooperatively to its receptor protein, thus mediating activation of the kinase.

About this Structure

1RGS is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains., Su Y, Dostmann WR, Herberg FW, Durick K, Xuong NH, Ten Eyck L, Taylor SS, Varughese KI, Science. 1995 Aug 11;269(5225):807-13. PMID:7638597 Page seeded by OCA on Sat May 3 07:28:38 2008

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