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Tdp-43
From Proteopedia
(Difference between revisions)
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TDP-43 helical stabilizers | TDP-43 helical stabilizers | ||
<StructureSection load='2n2cligalza0.pdb.gz' size='350' side='right' caption='Compound A is the best current binder to the healthy helical tdp-43' scene=''> | <StructureSection load='2n2cligalza0.pdb.gz' size='350' side='right' caption='Compound A is the best current binder to the healthy helical tdp-43' scene=''> | ||
| - | This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils. '''Tdp-43''' | + | This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils. '''Tdp-43'''. |
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== Function == | == Function == | ||
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| + | '''Tdp-43''' or '''TAR DNA-binding protein 43''' is a heterogeneous nuclear ribonucleoprotein which has crucial roles in gene expression and alternative splicing, stress response, neuronal functions such as neurite outgrowth and many other cellular processes<ref>PMID:17981595</ref>. | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. | + | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. |
| - | + | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 07:59, 2 January 2018
TDP-43 helical stabilizers
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