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Cathepsin
From Proteopedia
(Difference between revisions)
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**[[1mir]] - rPCTSB (mutant) - rat<br /> | **[[1mir]] - rPCTSB (mutant) - rat<br /> | ||
**[[4n4z]], [[4hwy]] - TbCTSB – ''Trypanosoma brucei''<br /> | **[[4n4z]], [[4hwy]] - TbCTSB – ''Trypanosoma brucei''<br /> | ||
| + | **[[5fpw]] – TbCTSB (mutant)<br /> | ||
* Cathepsin-B mature | * Cathepsin-B mature | ||
| Line 89: | Line 90: | ||
* Cathepsin-K mature | * Cathepsin-K mature | ||
| - | **[[4n79]] – hMCTSK<br /> | + | **[[4n79]], [[5tun]], [[4yva]] – hMCTSK<br /> |
| + | **[[5jh3]] – hMCTSK (mutant) <br /> | ||
| + | **[[5t6u]] – mMCTSK<br /> | ||
**[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]], [[3o0u]] – hMCTSK+ pyrimidine inhibitor<br /> | **[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]], [[3o0u]] – hMCTSK+ pyrimidine inhibitor<br /> | ||
**[[3mpe]], [[3mpf]] – hMCTSK (mutant) + pyrimidine inhibitor<br /> | **[[3mpe]], [[3mpf]] – hMCTSK (mutant) + pyrimidine inhibitor<br /> | ||
| Line 107: | Line 110: | ||
**[[1au2]] - hMCTSK+ propanone inhibitor<br /> | **[[1au2]] - hMCTSK+ propanone inhibitor<br /> | ||
**[[1atk]] – hMCTSK+guanidine inhibitor<br /> | **[[1atk]] – hMCTSK+guanidine inhibitor<br /> | ||
| - | **[[1vsn]], [[5j94]] - hMCTSK+ inhibitor<br /> | + | **[[1vsn]], [[5j94]], [[4x6h]], [[4x6i]] - hMCTSK+ inhibitor<br /> |
**[[2ato]] – hMCTSK+myocrisin<br /> | **[[2ato]] – hMCTSK+myocrisin<br /> | ||
**[[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor<br /> | **[[1u9v]], [[1u9x]], [[1mem]] – hMCTSK+piperazine inhibitor<br /> | ||
**[[1u9w]] - hMCTSK+imidazole inhibitor<br /> | **[[1u9w]] - hMCTSK+imidazole inhibitor<br /> | ||
| + | **[[5tdi]] – hMCTSK + odanacatib<br /> | ||
| + | **[[5tdi]] – hMCTSK + lichostatinal<br /> | ||
| + | **[[5ja7]] – hMCTSK (mutant) + effector<br /> | ||
**[[2ftd]] – MCTSK+azepan inhibitor – ''Macaca mulatta''<br /> | **[[2ftd]] – MCTSK+azepan inhibitor – ''Macaca mulatta''<br /> | ||
**[[2f7d]] – MCTSK (mutant)+nitrile inhibitor - rabbit<br /> | **[[2f7d]] – MCTSK (mutant)+nitrile inhibitor - rabbit<br /> | ||
| Line 135: | Line 141: | ||
* Cathepsin-L1 mature | * Cathepsin-L1 mature | ||
| - | **[[3iv2]] – hMCTSL1 (mutant) <br /> | + | **[[4axl]] – hMCTSL1 catalytic domain<br /> |
| + | **[[3iv2]], [[5i4h]] – hMCTSL1 (mutant) <br /> | ||
**[[3k24]] - hMCTSL1 (mutant) +tripeptide<br /> | **[[3k24]] - hMCTSL1 (mutant) +tripeptide<br /> | ||
**[[3of8]] - hMCTSL1 + dipeptidyl inhibitor<br /> | **[[3of8]] - hMCTSL1 + dipeptidyl inhibitor<br /> | ||
**[[2xu1]], [[2xu3]], [[2xu4]], [[2xu5]], [[2yj2]], [[2yj8]], [[2yj9]], [[2yjb]], [[2yjc]] - hMCTSL1 catalytic domain (mutant)+nitrile inhibitor<br /> | **[[2xu1]], [[2xu3]], [[2xu4]], [[2xu5]], [[2yj2]], [[2yj8]], [[2yj9]], [[2yjb]], [[2yjc]] - hMCTSL1 catalytic domain (mutant)+nitrile inhibitor<br /> | ||
| - | **[[3bc3]], [[3of9]] - hMCTSL1 +inhibitor<br /> | ||
**[[3h89]], [[3h8b]], [[3h8c]] - hMCTSL1 (mutant) + retro-binding inhibitor<br /> | **[[3h89]], [[3h8b]], [[3h8c]] - hMCTSL1 (mutant) + retro-binding inhibitor<br /> | ||
**[[3hwn]], [[3hha]] – hMCTSL1+pyrazole inhibitor<br /> | **[[3hwn]], [[3hha]] – hMCTSL1+pyrazole inhibitor<br /> | ||
| - | **[[3kse]] – hMCTSL1 (mutant)+stefin | + | **[[3kse]] – hMCTSL1 (mutant)+stefin<br /> |
| + | **[[4axm]], [[5mae]], [[5maj]], [[5f02]], [[3bc3]], [[3of9]] – hMCTSL1 catalytic domain + inhibitor<br /> | ||
* Cathepsin-L2 mature | * Cathepsin-L2 mature | ||
Revision as of 09:26, 29 March 2017
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3D Structures of Cathepsin
Updated on 29-March-2017
Cathepsin-C mature see Dipeptidyl peptidase-I
References
- ↑ Nomura T, Katunuma N. Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells. J Med Invest. 2005 Feb;52(1-2):1-9. PMID:15751268
- ↑ Mirkovic B, Renko M, Turk S, Sosic I, Jevnikar Z, Obermajer N, Turk D, Gobec S, Kos J. Novel Mechanism of Cathepsin B Inhibition by Antibiotic Nitroxoline and Related Compounds. ChemMedChem. 2011 May 20. doi: 10.1002/cmdc.201100098. PMID:21598397 doi:10.1002/cmdc.201100098
