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Metabotropic glutamate receptor

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Line 35: Line 35:
**[[4xas]], [[4xaq]] – hMGluR2 LBD + agonist<br />
**[[4xas]], [[4xaq]] – hMGluR2 LBD + agonist<br />
 +
**[[5kzq]], [[5kzn]] – hMGluR2 LBD + antagonist<br />
 +
**[[5cni]] – hMGluR2 LBD + Glu <br />
 +
**[[5cnj]] – hMGluR2 LBD + Glu analog<br />
*Metabotropic glutamate receptor 3
*Metabotropic glutamate receptor 3
 +
**[[5cnk]] – hMGluR3 LBD + Glu <br />
**[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br />
**[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br />
**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br />
**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br />
**[[3sm9]] - hMGluR3 + antagonist<br />
**[[3sm9]] - hMGluR3 + antagonist<br />
**[[4xar]] – hMGluR3 LBD + agonist<br />
**[[4xar]] – hMGluR3 LBD + agonist<br />
 +
**[[5cnm]] – hMGluR3 LBD + Glu analog<br />
*Metabotropic glutamate receptor 5
*Metabotropic glutamate receptor 5
Line 49: Line 54:
*Metabotropic glutamate receptor 7
*Metabotropic glutamate receptor 7
 +
**[[5c5c]] – hMGluR7 LBD (mutant)<br />
**[[3mq4]] – hMGluR7 LBD + antagonist<br />
**[[3mq4]] – hMGluR7 LBD + antagonist<br />
}}
}}

Revision as of 06:42, 26 June 2017

Structure of the glycosylated rat binding domain of the Metabotropic Glutamate Receptor, GluR1, bound to glutamate, Hepes and Mg+2 ions (1ewk)

Drag the structure with the mouse to rotate

3D structures of metabotropic glutamate receptor

Updated on 26-June-2017

See Also

Membrane Channels & Pumps
Ionotropic_Glutamate_Receptors
Alzheimer's Disease

References

  1. ↑ Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev. 2010 Sep;62(3):405-96. doi: 10.1124/pr.109.002451. PMID:20716669 doi:http://dx.doi.org/10.1124/pr.109.002451
  2. ↑ Johnson KA, Conn PJ, Niswender CM. Glutamate receptors as therapeutic targets for Parkinson's disease. CNS Neurol Disord Drug Targets. 2009 Dec;8(6):475-91. PMID:19702565
  3. ↑ Niswender CM, Conn PJ. Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol. 2010;50:295-322. doi:, 10.1146/annurev.pharmtox.011008.145533. PMID:20055706 doi:http://dx.doi.org/10.1146/annurev.pharmtox.011008.145533
  4. ↑ Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, Morikawa K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature. 2000 Oct 26;407(6807):971-7. PMID:11069170 doi:10.1038/35039564

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Michal Harel, Alexander Berchansky, Wayne Decatur, Nikki Hunter

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