1rhp
From Proteopedia
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'''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLATELET FACTOR 4''' | '''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLATELET FACTOR 4''' | ||
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[[Category: Zhang, X.]] | [[Category: Zhang, X.]] | ||
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Revision as of 04:30, 3 May 2008
CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLATELET FACTOR 4
Overview
The crystal structure of human platelet factor 4 (PF4) has been solved to a resolution of 2.4 A by molecular replacement and refined to an R-factor of 24.1%. The structure consists of four polypeptide chains which form a tetrameric unit. N-terminal residues, previously defined as a random coil or extended loop region, form antiparallel beta-sheet-like structures that form noncovalent associations between dimers. These antiparallel beta-sheet-like structures are positioned lateral to the beta-bilayer motif and stabilize the tetrameric unit. A positively charged ring of lysine and arginine side chains encircles the PF4 tetramer sphere, presenting multiple potential sites and orientations for heparin binding. The electrostatic interactions of multiply charged amino acid side chains and hydrogen bonding interactions at the AB/CD dimer interface serve to stabilize the tetrameric structure further.
About this Structure
1RHP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of recombinant human platelet factor 4., Zhang X, Chen L, Bancroft DP, Lai CK, Maione TE, Biochemistry. 1994 Jul 12;33(27):8361-6. PMID:8031770 Page seeded by OCA on Sat May 3 07:30:42 2008
